EXPERIMENTAL OBSERVATION ON ACUPUNCTURE TREATMENT OF MULTIPLE AORTO—ARTERITIS IN THE RABBIT

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EXPERIMENTAL OBSERVATION ON ACUPUNCTURE TREATMENT OF MULTIPLE AORTO-ARTERITIS IN THE RABBIT

Objective: To study mechanisms of acupuncture in the treatment of multiple aorto arteritis. Methods: A total of 100 rabbits were randomly divided into control, model, acupuncture , Western medicine and Chinese medicine groups, with 20 cases being in each group. Aorto arteritis model was produced by intramuscular injection of human's arteritis tissue homogenate + died bacille Calmette Guerin (BCG) near the femoral artery and posterior tibial artery and the auricular root. Acupoint Renying (ST 9), Jiquan (HT 1), Fengchi (GB 20), Taiyuan (LU 9), Pishu (BL 20) and Shenshu (BL 23) were punctured and stimulated by twirling, lifting and thrusting the needles with hand repeatedly for 1-3 min. Animals of Western medicine group were treated by intramuscular injection of dibazol, and those of Chinese medicine group treated with intramuscular injection of compound red sage root injection (5 mL). Plasma WBC, neutrophilic granulocyte and lymphocyte counts, serum IgG, IgA, IgM, IgE contents, serum C 3 and C 4 were detected. Results: After acupuncture treatment, both plasma WBC and lymphocyte counts increased significantly in comparison with model group (P<0.01), while neutrophilic granulocyte count lowered strikingly (P<0.01). While in Western medicine and Chinese drug groups, neutrophilic granulocyte counts were apparently lower than that of model group, while lymphocyte counts of these medication groups were higher than that of model group, WBC count of Chinese drug group was markedly higher than that of model group (P<0.05). Determination of the immunoglobulin displayed that IgG, IgA and IgM contents of acupuncture group were significantly higher than that of model group (P<0.01), while those of the two medication groups were higher or remarkably higher (IgG) than that of model group. Serum C 3 and C 4 contents of acupuncture group, two medication groups were all significantly higher than those of model group (P<0.05-0.01). Conclusion: Acupuncture treatment induced improvement of hematology, serum immunoglobulin and serum complement contents may contribute to the therapeutic effect of acupuncture in relieving aorto arteritis.