STUDY ON THE THERAPEUTIC EFFECT AND MECHANISMS OF AURICULAR ACUPUNCTURE FOR TREATMENT OF EXPERIMENTAL DIABETES MELLITUS IN THE RABBIT

Ｉｎｒｅｃｅｎｔｙｅａｒｓ,ｒｅｐｏｒｔｓｏｎａｃｕｐｕｎｃｔｕｒｅｔｒｅａｔｍｅｎｔｏｆｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ(ＤＭ )ａｒｅｉｎｃｒｅａｓ ｉｎｇ.Ｒｅｓｕｌｔｓｉｎｄｉｃａｔｅｔｈａｔａｃｕｐｕｎｔｕｒｅｐｏｓｓｅｓｓｅｓｒｅｇｕｌａｔｉｖｅｅｆｆｅｃｔｏｎｔｈｅｆｕｎｃｔｉｏｎａｌａｃｔｉｖｉｔｙａｎｄｉｎｓｕｌｉｎｓｅｃｒｅｔｉｏｎｏｆｔｈｅｐａｎｃｒｅａｔｉｃｉｓｌｅｔβ ｃｅｌｌｓ,ａｌｓｏｃａｎｍｏｄｕｌａｔｅｆｕｎｃｔｉｏｎｓｏｆｔｈｅｃｅｎｔｒａｌｎｅｒ ｖｏｕｓｓｙｓｔｅ…

STUDY ON THE THERAPEUTIC EFFECT AND MECHANISMS OF AURICULAR ACUPUNCTURE FOR TREATMENT OF EXPERIMENTAL DIABETES MELLITUS IN THE RABBIT

In the present study,fasting blood glucose (FBG)concentration and serum insulin concentration and chenges of the ultramicrostructure of the pancreatic islet cells are used as the indexes to evaluate the therapeutic effect of aurioular acupuncture in the treatment of experimental diabetes mellitus(DM)and to analyze ist mechanisms in the rabbit .Thirty-two rabbits are randomly divided into control,model,acupuncture and medication groups with 8 cases being in each group.DM model is established by intravenous injection of 4% Alloxan (150mg/kg).Otopoints used are low-resistanoa points of Yidan(MA-SC 6),Neifenmi (MA-IC 3), Jiaogan(MA-AH 7), Fei (MA-IC 1), Wei (MA-IC),Shen (MA-SC),etc..Inmedication group, the animals are fed with glbenzcyclamied, ( 1.25 mg/kg/day). The treatment of both groups is given once daily, 20 sessions altogether. Results display that after 2 courses of treatment (20 sessions), in comparison with pre-treatment and model group, FBG contents in acupuncture and medication groupsd decreased significantly (P＜0.01), while insulin contents of acupuncture and medication groups increaesd remarkably (P＜0.05). No significant differences between acupuncture and medication groups in FBG and insulin contents. Accordingly, electron microscopic dbservation shows some improvements in partial organells as Iysosome being fewer,reduction of the nucleolar swelling, etc. in both acupucture group and medication group. It shows that restoration of the structure of islet β-cells of the pancreas, increase of the synthesis and release of insulin as well as the activity of insulin mayy contribute to the effect of auricular acupuncture in lowring blood glucose level in DM rabbits.