| 纤维蛋白原活性在冠心病发展中的作用 |
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| 引用本文： | 赵国胜,杨会杰,周志泳,张嘉晴.纤维蛋白原活性在冠心病发展中的作用[J].中国病理生理杂志,2001,17(1):61-63. |
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| 作者姓名： | 赵国胜 杨会杰 周志泳 张嘉晴 |
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| 作者单位： | 皖南医学院心血管功能研究所, 安徽 芜湖 241001 |
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| 摘 要： | 目的:探讨纤维蛋白原活性升高在冠心病发展中的可能作用。方法:用血液流变学方法检测冠心病患者稳定期和心绞痛患者的纤维蛋白原活性。结果:冠心病患者血浆纤维蛋白原水平及其血浆粘性显著高于正常对照组(P＜0.01,P＜0.05),并且心绞痛患者纤维蛋白原活性和血小板聚集性(Pt max、Pt H、Pt K)也同时高于正常对照组(P＜0.01),并发现心绞痛组纤维蛋白原活性值与Pt max、PtH呈显著负相关(r＝-0.8379,P＜0.01;r=-0.8784,P＜0.01)。结论:纤维蛋白原活性升高在冠心病发展中起一定作用。
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| 关 键 词： | 纤维蛋白原 血小板聚集 动脉粥样硬化 |
| 文章编号： | 1000-4718(2001)01-0061-03 |
| 收稿时间： | 1999-12-01 |
| 修稿时间： | 1999年12月1日 |
Role of fibrinogen
activity in the progress of coronary artery disease |
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| ZHAO Guo-sheng,YANG Hui-jie,ZHOU Zhi-yong,ZHANG Jia-qing.Role of fibrinogen
activity in the progress of coronary artery disease[J].Chinese Journal of Pathophysiology,2001,17(1):61-63. |
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| Authors: | ZHAO Guo-sheng YANG Hui-jie ZHOU Zhi-yong ZHANG Jia-qing |
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| Institution: | Institute of Cardiovascular Function, Wannan Medical College, Wuhu 241001, China |
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| Abstract: | AIM: To detect the role of fibrinogen activity (Fa) in the progress of coronary artery disease (CHD).METHODS:Fa was measured with hemorheology methods in patients with CHD stable phase (n=30) and angina pectoris (n=27).RESULTS: (1) Levels of plasmatic fibrinogen and plasmatic viscosity in patients with CHD were higher than that of control group (P<0 01,P<0 05).(2)Fa and platelet aggregation activity (Pt max, Pt H, Pt K ) in patients with CHD angina pectoris were very much higher than that of control group (P<0 01, respectively).(3)There was a negative correlation between PT max, Pt H and Fa(r=-0.8379,P<0.01;r=-0.8784,P<0.01 respectively) in patients with CHD angina pectoris.CONCLUSION: Fa may play a role in the progress of CHD. |
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| Keywords: | Fibrinogen Platelet aggregation Atherosclerosis |
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