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205例儿童急性淋巴细胞白血病疗效分析
引用本文:吴敏媛,赵全.205例儿童急性淋巴细胞白血病疗效分析[J].中华血液学杂志,1994,15(5):248-250.
作者姓名:吴敏媛  赵全
作者单位:北京儿童医院
摘    要:报告205例小儿急性淋巴细胞白血病(ALL),诱导缓解期采用强烈CODP+L-ASP和COAP+L-ASP方案,联合大剂量氨甲喋呤(HD-MTX)及头颅放疗(18Gy)进行庇护所预防。使5年无病生存率(EFS)达到74.4%,中枢神经系统白血病复发率降至1.5%,睾丸白血病复发率降至3.4%。治疗效果表明:早期强烈化疗及有效的庇护所预防是减少骨髓及髓外复发,提高EFS的关键。

关 键 词:白血病,淋巴细胞,急性,无病生存率,白血病治疗

ANAL YSlS OF THE TREATMENT lN 205 CHlLDREN WlTHACUTE LYMPHOBLASTlC LEUKEMlA
Wu Mingyuan,Zhao Qian,Hu Yamei.ANAL YSlS OF THE TREATMENT lN 205 CHlLDREN WlTHACUTE LYMPHOBLASTlC LEUKEMlA[J].Chinese Journal of Hematology,1994,15(5):248-250.
Authors:Wu Mingyuan  Zhao Qian  Hu Yamei
Abstract:he clinical therapeutic results in 205 children withacute lymphoblastic leukemia were analysed retrospecti-vely. Five-years event-free survival (EFS) of the newlydiagnosed patients received remission intensifiedchemotherapy (CODP or COAP regimen),followinggiven high dose methotrexate (HD-MTX) and then18Gy cranial irradiation,was 74. 4 % overall.The CNSand testicular relapse rates were significantly decreasedto 1.5% and 3. 4% respectively.These results showedthat the intensified induction chemotherapy and effectiveshelter prophylaxis were the key to elevate the EFS anddecrease the relapse.
Keywords:Acute lymphoblastic leukemia Shel-ter prophylaxis Event-free survival  
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