| 205例儿童急性淋巴细胞白血病疗效分析 |
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| 引用本文： | 吴敏媛,赵全.205例儿童急性淋巴细胞白血病疗效分析[J].中华血液学杂志,1994,15(5):248-250. |
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| 作者姓名： | 吴敏媛 赵全 |
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| 作者单位： | 北京儿童医院 |
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| 摘 要： | 报告２０５例小儿急性淋巴细胞白血病（ＡＬＬ），诱导缓解期采用强烈ＣＯＤＰ＋Ｌ－ＡＳＰ和ＣＯＡＰ＋Ｌ－ＡＳＰ方案，联合大剂量氨甲喋呤（ＨＤ－ＭＴＸ）及头颅放疗（１８Ｇｙ）进行庇护所预防。使５年无病生存率（ＥＦＳ）达到７４．４％，中枢神经系统白血病复发率降至１．５％，睾丸白血病复发率降至３．４％。治疗效果表明：早期强烈化疗及有效的庇护所预防是减少骨髓及髓外复发，提高ＥＦＳ的关键。
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| 关 键 词： | 白血病，淋巴细胞，急性，无病生存率，白血病治疗 |
ANAL YSlS OF THE TREATMENT lN 205 CHlLDREN WlTHACUTE LYMPHOBLASTlC LEUKEMlA |
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| Wu Mingyuan,Zhao Qian,Hu Yamei.ANAL YSlS OF THE TREATMENT lN 205 CHlLDREN WlTHACUTE LYMPHOBLASTlC LEUKEMlA[J].Chinese Journal of Hematology,1994,15(5):248-250. |
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| Authors: | Wu Mingyuan Zhao Qian Hu Yamei |
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| Abstract: | he clinical therapeutic results in 205 children withacute lymphoblastic leukemia were analysed retrospecti-vely. Five-years event-free survival (EFS) of the newlydiagnosed patients received remission intensifiedchemotherapy (CODP or COAP regimen),followinggiven high dose methotrexate (HD-MTX) and then18Gy cranial irradiation,was 74. 4 % overall.The CNSand testicular relapse rates were significantly decreasedto 1.5% and 3. 4% respectively.These results showedthat the intensified induction chemotherapy and effectiveshelter prophylaxis were the key to elevate the EFS anddecrease the relapse. |
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| Keywords: | Acute lymphoblastic leukemia Shel-ter prophylaxis Event-free survival |
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