176例左氧氟沙星不良反应分析

目的:了解左氧氟沙星所致药物不良反应情况,探讨产生原因、影响因素及处理方法.方法:在2 234份不良反应报告表中检索左氧氟沙星引发不良反应的病例,按患者性别、年龄、既往不良反应史、给药途径、临床表现、处理方法及结果等分类进行统计分析.结果:2 234份不良反应病例表中,176例由使用左氧氟沙星引起(占7.88%).56.82%的患者既往无药物不良反应史,93.75%的患者通过静脉给药,90.91%的不良反应出现在用药过程中,其中85.79%的患者治愈或好转,1例留有后遗症.结论:左氧氟沙星引起的不良反应发生率较低,如处理适当基本能痊愈,但临床医生在选用该药时仍应考虑多方面因素.

Analysis of 176 adverse drug reactions of levofloxacin

Objective:To investigate the adverse drug reaction (ADR) caused by levofloxacin and discuss the factors affecting the ADR. Methods:2 234 cases of ADR report in terms of patients' gender, age, ADR history, route of medication, clinical manifestation, processing methods and results were statistically analyzed. Results:Of the 2 234 cases of ADR report, 176 cases were caused after taking levofloxacin,accounting for 7.88% . Thereinto,56.82% of the patients have no record of ADR history. 93.75% of the patients take the medicine by vein. 90. 91 % of the ADR cases happened in the process of taking the medicine. 85.79 % of the patients recovered or improved, with only one case of sequela. Conclusion:The ADR rate caused by levofloxacin is low and can be cured mostly. But several factors should be taken into consideration in choosing the drug to avoid the occurrence of ADR.