MMP-14 在乳腺癌中的表达及临床意义

 目的 检测膜型-1基质金属蛋白酶(MMP-14)在乳腺癌中的表达并探讨其临床意义。方法 采用免疫组化的方法检测46例乳腺癌手术后标本中MMP-14蛋白的表达，探讨MMP-14表达与乳腺癌临床病理因子的关系。结果 MMP-14蛋白在正常乳腺组织中没有表达，在乳腺癌中表达的阳性率是52．2％。在Ⅰ期、Ⅱ期和Ⅲ期乳腺癌中表达的阳性率分别为12．5％、54．8％和85．7％(P<0．05)；在T1、T2和T3三组中的阳性率分别为11．1％、59．4％和8t)．O％(P<0．05)；在N0、N1和N2三组中的阳性率分别为27．3％、66．7％和100％(P<0．05)。MMP-14蛋白的表达与VEGR呈正相关(P<0．05)，但与ER、PR、c-erbB-2的状况无统计学差异(P>0．05)。结论 MMP-14的蛋白质在乳腺癌中的表达与肿瘤分期、肿瘤大小、淋巴结转移和VEGF呈正相关，有可能为判断乳腺癌浸润转移能力的一个指标。

Significance of MMP-14 Expression in Breast Cancer

Objective 　To investigate the expression and clinical significance of MMP-14 protein in human breast cancers. Methods 　Forty-six human breast cancer tissues were collected. MT1-MMP protein was detected by immunohistochemist ry assay and their correlations with clinicopathological factors were analyzed. Results 　The expression of MMP-14 protein was negative in normal breast tissues and positive in 52. 2 % of forty-six breast cancers tissues. The positive rates were 12. 5 % ,54. 8 % and 85. 7 % in stageⅠ, stage Ⅱ and stage Ⅲ human breast cancers , respectively ( P < 0. 05) , and 11. 1 % , 59. 4 % and 80. 0 % in the group of T1 ,T2 and T3 ( P < 0. 05) , and 27. 3 % ,66. 7 % and 100. 0 % in the group of N0 ,N1 and N2 ( P < 0. 05) . MMP-14 protein showed positive relation with VEGF ( P < 0. 05) , but no relations with and ER ,PR or c-erbB-2 ( P > 0. 05) . Conclusion 　MMP-14 protein in human breast cancers had positive correlation with the stage ,the tumor size ,lymph node metastasis and VEGF. It can be a predictor for the ability of breast cancer invasion and metatasis.