Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia |
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| Authors: | Christine Mesavage Carol S. Nance David B. Flannery Debra L. Weiner Sharon F. Suchy Barry Wolf |
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| Affiliation: | Department of Human Genetics and Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Richmond, Virginia, U.S.A. |
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| Abstract: | A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder. |
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| Keywords: | Amniotic fluid glycine nonketotic hyperglycinemia prenatal diagnosis serine |
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