抗小叶增生合剂对乳腺小叶增生模型大鼠的影响

目的观察抗小叶增生合剂对乳腺增生病动物模型的治疗作用。方法采用苯甲酸雌二醇联合黄体酮肌注的方法,复制大鼠乳腺增生模型,用抗小叶增生合剂30.0,15.0,7.5ml/kg 3个剂量治疗30天,测定大鼠乳头直径,观察乳头大体形态变化及显微镜下乳腺组织变化,观察对血液流变学的影响;测定血清苯甲酸雌二醇含量。结果抗小叶增生合剂能明显减小大鼠增生乳头直径,减少乳腺小叶数、腺泡数和腺泡腔直径,改善血液流变学参数,显著减轻乳头形态学症状和降低血清苯甲酸雌二醇含量。结论抗小叶增生合剂对雌激素引起的大鼠乳腺增生病有较好的疗效。

An experimental study of the effects of Kangruxianxiaoyezengsheng on lobular hyperplasia of mammary glands in model rats

Objective To observe the effect of Kangruxianxiaoyezengsheng on rats with mastoplasia. Methods After benzoate estradiol and progestogen had been injected into rats, the mastoplasia models were produced. The model rats were treated with Kangruxianxiaoyezengsheng （30.0, 15.0, 7.5ml/kg） for 30 days, the mammary papilla diameter of the rats in all groups were measured, morphologic changes of mammary papilla and the changes of mammary gland were observed under microscope, the content of estradiol in blood serum and blood rheology were determined by radio - immunity. Results Kangruxianxiaoyezengsheng could significantly shrink the mammary papilla＇s diameter of the mastoplasia rats, lessen mammary papilla＇s symptoms in morphology, reduce the quantity of lobule of mammary gland, lobule- alveolus in mammary gland and the diameter of acinar lumina. Kangruxianxi- aoyezengsheng could also significantly improve blood rheological nature and reduce content of estradiol in blood serum. Conclusions Kangruxianxiaoyezengsheng can be effective for rat＇s mastoplasia induced by benzoate estradiol.