医院深部真菌感染危险因素分析

目的：了解医院内深部真菌感染情况，为预防和治疗医院深部真菌感染提供资料。方法：采用回顾性调查的方法，对2001年医院深部真菌感染进行研究。结果：61例深部真菌感染中，60岁以上有32人，平均住院时间67天；基础疾病为呼吸系统疾病的有19人，占31．15％，恶性肿瘤16人，占26．23％；病原菌以白色念珠菌为主，有34株，占55．74％；感染部位为下呼吸道有31人，占50．82％。有39例患在发生感染前使用了抗生素，其中二联及二联以上19例，占48．72％(19／39)。有8例患在治疗性使用酮康唑时合用了强的松或地塞米松。结论：对院内深部真菌感染应予以高度警惕，预防为主，合理应用抗生素及皮质类固醇激素，注意它们与抗真菌药物合用时的相互作用，保护患的防御屏障，及时有效地控制院内深部真菌感染。

Risk factors of nosocomial infection with deep fungi

Objective To evaluate the nosocomial infection with deep fungi. Methods Nosocomial infection cases with deep fungi in 2001 in a hospital were investigated by retrospective methods. Results The average hospitalization time was 67 days, 19 patients (31.15% ) had respiratory system diseases, 16 patients (26.23% ) with malignant tumor, 34 strains (55.74% ) of pathogens were Candida albicans , the main infection site was lower respiratory tract, which accounting for 50.82% , 39 patients received antimicrobial agents before infection developed, 19 patients (48.72% ) used at least 2 kinds of antimicrobial agents, 8 patients used prednisone or dexamethasone when they received ketoconazole simultaneously. Conclusion The prevention of nosocomial infection with deep fungi is important, the antimicrobial agents and corticosteroid should be used rationally.