Tupuseleiamides and basiliskamides,new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat |
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| Authors: | Barsby Todd Kelly Michael T Andersen Raymond J |
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| Affiliation: | Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, 2036 Main Mall, Vancouver, Canada. |
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| Abstract: | Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of 1 to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (2) show potent in vitro anti-Candida activity. |
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