| SR-BI在胆固醇结石病人胆囊粘膜上皮中的表达 |
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| 引用本文： | 李承龙,冯贤松,谢玉宏,朱求实. SR-BI在胆固醇结石病人胆囊粘膜上皮中的表达[J]. 腹部外科, 2006, 19(1): 55-56 |
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| 作者姓名： | 李承龙 冯贤松 谢玉宏 朱求实 |
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| 作者单位： | 430022,武汉,华中科技大学同济医学院附属协和医院普外科;430022,武汉,华中科技大学同济医学院附属协和医院普外科;430022,武汉,华中科技大学同济医学院附属协和医院普外科;430022,武汉,华中科技大学同济医学院附属协和医院普外科 |
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| 摘 要： | 目的探讨SR-BI在胆囊胆固醇结石病人胆囊粘膜中的表达和分布,了解其与胆固醇结石发病之间的关系。方法应用免疫组化方法检测SR-BI在22例胆固醇结石病人胆囊粘膜(结石组)和13例非胆囊疾病病人胆囊粘膜(对照组)标本中的表达。结果SR-BI表达于胆囊粘膜上皮细胞顶侧,结石组的SR-BI表达显著低于对照组,其差异具有统计学意义。结论胆固醇结石病人胆囊粘膜上皮细胞中SR-BI表达减弱,可能在胆固醇结石发病机制中起一定作用。
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| 关 键 词： | 胆结石 胆固醇 免疫组织化学 |
| 修稿时间： | 2005-09-09 |
Expression of scavenger receptor class B type I (SR-BI) in gallbladder epithelium of patients with cholesterol gallstone |
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| LI Cheng-long,FENG Xian-song,XIE Yu-hong,et al.. Expression of scavenger receptor class B type I (SR-BI) in gallbladder epithelium of patients with cholesterol gallstone[J]. Journal of Abdominal Surgery, 2006, 19(1): 55-56 |
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| Authors: | LI Cheng-long FENG Xian-song XIE Yu-hong et al. |
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| Affiliation: | LI Cheng-long,FENG Xian-song,XIE Yu-hong,et al.Department of General Surgery,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022 China |
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| Abstract: | Objective To investigate the expression and distribution of scavenger receptor class B type I(SR-BI) in the mucosa of patients with cholesterol gallstone,and analyze their relationship.Methods The specimens of 22 patients with cholesterol gallstone and 13 controls were studied by immunohistochemical method to detect the SR-BI protein expression.Results SR-BI was expressed in the apical domain of gallbladder epithelial cells.The expression of SR-BI in gallstone patients was significantly decreased as compared with that in the controls.Conclusion The expression of SR-BI protein is decreased in cholesterol gallstone patients,indicating that SR-BI may have some effects on the pathogenesis of cholesterol gallstone. |
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| Keywords: | Cholelithiasis Cholesterol Immunohistochemistry |
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