| 口服补镁对老年2型糖尿病大鼠胰岛素敏感性的影响 |
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| 引用本文： | 钟文雯,谷昭艳,方福生,闫双通,李春霖. 口服补镁对老年2型糖尿病大鼠胰岛素敏感性的影响[J]. 军医进修学院学报, 2011, 32(8): 858-859,865. DOI: CNKI:11-3275/R.20110225.1445.000 |
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| 作者姓名： | 钟文雯 谷昭艳 方福生 闫双通 李春霖 |
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| 作者单位： | 解放军总医院,南楼内分泌科,北京,100853 |
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| 基金项目： | 国家自然科学基金项目(30901187)~~ |
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| 摘 要： | 目的研究口服补镁对老年2型糖尿病大鼠胰岛素敏感性的影响。方法给2型糖尿病大鼠动物模型口服补镁,应用高胰岛素、正葡萄糖钳夹技术测定稳态下葡萄糖输注率、空腹血糖、空腹胰岛素及血浆镁离子浓度等指标。结果中、高剂量口服补镁可降低空腹血糖达11.3%和21.9%,胰岛素水平下降分别达25.4%和38.7%,钳夹实验中稳态葡萄糖输注率也有明显提高。结论口服补镁可显著改善老年2型糖尿病大鼠胰岛素敏感性。
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| 关 键 词： | 镁 2型糖尿病 胰岛素敏感性 大鼠 |
Effect of oral magnesium supplementation on insulin sensitivity in aged rats with type 2 diabetes |
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| ZHONG Wen-wen,GU Zhao-yan,FANG Fu-sheng,YAN Shuang-tong,LI Chun-lin. Effect of oral magnesium supplementation on insulin sensitivity in aged rats with type 2 diabetes[J]. Academic Journal of Pla Postgraduate Medical School, 2011, 32(8): 858-859,865. DOI: CNKI:11-3275/R.20110225.1445.000 |
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| Authors: | ZHONG Wen-wen GU Zhao-yan FANG Fu-sheng YAN Shuang-tong LI Chun-lin |
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| Affiliation: | ZHONG Wen-wen,GU Zhao-yan,FANG Fu-sheng,YAN Shuang-tong,LI Chun-linDepartment of Geriatric Endocrinology,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To investigate the effect of oral magnesium on insulin sensitivity in aged rats with type 2 diabetes.Methods An aged rat model of type 2 diabetes was induced by oral magnesium.Glucose infusion rate and levels of fasting glucose,insulin,and plasma magnesium ions in the rat model were measured using the euglycaemic-hyperinsulinaemic clamp technique.Results The medium and high doses of oral magnesium reduced the fasting blood glucose by 11.3% and 21.9%,and the insulin level by 25.4% and 38.7%,respect... |
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| Keywords: | Magnesium Diabetes Mellitus Type 2 Insulin Sensitivity Rats |
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