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| 乳腺癌分子分型与腋窝淋巴结转移相关性分析 | |
| 引用本文： | 谢文秀,杨俊兰,焦顺昌,戴广海,李自健,游俊浩. 乳腺癌分子分型与腋窝淋巴结转移相关性分析[J]. 军医进修学院学报, 2011, 32(7): 708-711 |
| 作者姓名： | 谢文秀 杨俊兰 焦顺昌 戴广海 李自健 游俊浩 |
| 作者单位： | 1. 海军总医院特需医疗部,北京,100048 2. 解放军总医院肿瘤科,北京,100853 3. 武汉161医院肿瘤科,武汉,430010 |
| 摘 要： | 目的 分析乳腺癌分子分型与腋窝淋巴结转移的相关性.方法 2000年1月-2009年12月在解放军总医院就诊的Ⅰ-Ⅲ期乳腺癌患者共773例,依据雌激素受体(ER)、孕激素受体(PR)、表皮生长因子受体-2(HER-2)的表达将其近似划分为Luminal A型(ER+和/或PR+,HER2-)、Luminal B1型(ER+,PR+,HER-2+)、Luminal B2型(ER+或PR+,HER-2+)、HER-2型(ER-,PR-,HER-2+)和Basal型(ER-,PR-,HER-2-)5个分子亚型,对比腋窝淋巴结转移阳性率的差异.对影响腋窝淋巴结转移的因素进行Logistic回归分析.结果 Luminal B1型腋窝淋巴结转移率最高,HER-2型、Luminal B2型次之,再次为Basal型,Luminal A型最低,各分子亚型的腋窝淋巴结转移率有显著差异(P＜0.05);Logistic回归分析提示是否为luminal B1型、Luminal A型、年龄、肿瘤直径、组织学分级以及是否为黏液癌或早期浸润癌是影响腋窝淋巴结转移的独立因素(P＜0.05).结论 表达HER-2的LuminalB1型、HER-2型及Luminal B2型具有高腋窝淋巴结转移率的特点,分子分型与腋窝淋巴结转移相关. |
| 关 键 词： | 乳腺肿瘤 分子分型 腋窝淋巴结 |
Correlation between molecular subtype and axillary lymph node metastasis of breast cancer |
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| XIE Wen-xiu , YANG Jun-lan , JIAO Shun-chang , DAI Guang-hai , LI Zi-jian , YOU Jun-hao. Correlation between molecular subtype and axillary lymph node metastasis of breast cancer[J]. Academic Journal of Pla Postgraduate Medical School, 2011, 32(7): 708-711 | |
| Authors: | XIE Wen-xiu YANG Jun-lan JIAO Shun-chang DAI Guang-hai LI Zi-jian YOU Jun-hao |
| Affiliation: | XIE Wen-xiu1,YANG Jun-lan2,JIAO Shun-chang2,DAI Guang-hai2,LI Zi-jian3,YOU Jun-hao2 1Special Care Medical Center,Chinese PLA Navy General Hospital,Beijing 100048,China,2Department of Oncology,Chinese PLA General Hospital,Beijing 100853,3Department of Oncology,Chinese PLA 161 Hospital,Wuhan 430010,Hubei Province |
| Abstract: | Objective To analyze the correlation between molecular subtypes and axillary lymph node(ALN) metastasis of breast cancer.Methods A total of 773 patients with breast cancer at 1-3 stages admitted to Chinese PLA General Hospital from January 2000 to December 2009 were enrolled in this study.Breast cancer were divided into luminal A molecular subtype(ER+ and/or PR+,HER2-),luminal B1 molecular subtype(ER+,PR+,HER2+),luminal B2 molecular subtype(ER+ or PR+,HER-2+),HER-2 molecular subtype(ER-,PR-,HER-2+) and basa... |
| Keywords: | Breast Neoplasms Molecular Typing Axillary Lymph Node |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |