| 全反式维甲酸对颈动脉内膜损伤后MMP-2和TIMP-2表达的影响 |
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| 引用本文： | 郭英华,刘长庭,何建国.全反式维甲酸对颈动脉内膜损伤后MMP-2和TIMP-2表达的影响[J].军医进修学院学报,2011,32(7):739-742. |
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| 作者姓名： | 郭英华 刘长庭 何建国 |
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| 作者单位： | 1. 解放军总医院南楼呼吸科,北京,100853
2. 中国医学科学院阜外心血管病医院,北京,100037 |
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| 基金项目： | 国家自然科学基金项目(81000018); 解放军总医院苗圃基金重点项目(10KMZ04)~~ |
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| 摘 要： | 目的 观察全反式维甲酸(ATRA)对血管损伤后细胞外基质以及TIMP-2和MMP-2表达的影响.方法 36只新西兰大白兔随机分为正常对照组、模型组和ATRA干预组.分析动脉内膜增生、管腔狭窄和细胞外基质沉积情况,Western blot 方法检测肺组织MMP-2和TIMP-2表达.结果 内膜损伤后ATRA干预可抑制MMP-2蛋白表达,促进TIMP-2蛋白表达;ATRA干预组的内膜增生程度轻于模型组,血管新生内膜中细胞外基质沉积也明显减少(P＜0.05).结论 ATRA在血管内膜损伤早期能促进TIMP-2表达、抑制MMP-2表达,抑制细胞外基质沉积和平滑肌细胞迁移,抑制内膜过度增生.
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| 关 键 词： | 全反式维甲酸 动脉内膜 MMP-2 TIMP-2 |
Effect of all-transretinoic acid on expression of MMP-2 and TIMP-2 in injured carotid artery of rabbits |
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| GUO Ying-hua
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LIU Chang-ting
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HE Jian-guo.Effect of all-transretinoic acid on expression of MMP-2 and TIMP-2 in injured carotid artery of rabbits[J].Academic Journal of Pla Postgraduate Medical School,2011,32(7):739-742. |
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| Authors: | GUO Ying-hua LIU Chang-ting HE Jian-guo |
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| Institution: | GUO Ying-hua1,LIU Chang-ting1,HE Jian-guo2 1Department of Geriatric Respiratory Medicine,Chinese PLA General Hospital,Beijing 100853,China,2Fuwai Hospital Cardiovascular Diseases,Chinese Academy of Medical Sciences,Beijing 100037 |
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| Abstract: | Objective To observe the effect of all-transretinoic acid(ATRA) on expression of MMP-2 and TIMP-2 in injured carotid artery of rabbits.Methods Thirty-six rabbits were randomly allocated into normal control group,model group and ATRA treatment group.Proliferation of tunica intima,lumen stricture and deposition of extracellular matrix in injured carotid artery of rabbits were analyzed.Expression of MMP-2 and TIMP-2 in lung tissues was detected by Western blot.Results Treatment of ATRA could inhibit the expres... |
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| Keywords: | All Trans Retinoic Acid Intima MMP-2 TIMP-2 |
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