| 碳青霉烯类抗生素联合舒巴坦治疗耐药鲍曼不动杆菌导致的医院获得性肺炎 |
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| 引用本文： | 王韧韬,佘丹阳.碳青霉烯类抗生素联合舒巴坦治疗耐药鲍曼不动杆菌导致的医院获得性肺炎[J].军医进修学院学报,2011,32(7):687-689. |
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| 作者姓名： | 王韧韬 佘丹阳 |
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| 作者单位： | 解放军总医院呼吸内科,北京,100853 |
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| 基金项目： | 解放军总医院苗圃基金项目(07MP13) |
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| 摘 要： | 目的 了解碳青霉烯类抗生素联合舒巴坦治疗碳青霉烯类耐药鲍曼不动杆菌导致的医院获得性肺炎的临床疗效.方法 对2007年10月-2009年4月在我科确诊为对碳青霉烯类抗生素耐药鲍曼不动杆菌医院获得性肺炎(Hospital-Aquired Pneumonia,HAP)17例患者,采用碳青霉烯类抗生素联合舒巴坦治疗(亚胺培南西司他丁钠0.5g静滴1/6h或美洛培南0.5g静滴1/6h+舒巴坦lg静滴1/8h),记录患者发病时的临床特征及治疗终点的临床反应及30d病死率.结果 17例患者分离出的鲍曼不动杆菌菌株,全部对碳青霉烯类抗生素耐药,对环丙沙星、阿米卡星、米诺环素的耐药率分别为100%,94.1%,70.6%;碳青霉烯类抗生素联合舒巴坦治疗3日临床好转14例,治疗终点(End 0fTherapy,EOT)治愈好转11例,30d归因死亡3例.结论 碳青霉烯类抗生素联合舒巴坦治疗策略的临床反应良好.
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| 关 键 词： | 多耐药鲍曼不动杆菌 碳青霉烯 舒巴坦 临床特征 院内感染 |
Treatment of hospital-acquired pneumonia induced by drug-resistant Acinetobacter baumannii with carbapenem and sulbactam |
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| WANG Ren-tao
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SHE Dan-yang.Treatment of hospital-acquired pneumonia induced by drug-resistant Acinetobacter baumannii with carbapenem and sulbactam[J].Academic Journal of Pla Postgraduate Medical School,2011,32(7):687-689. |
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| Authors: | WANG Ren-tao SHE Dan-yang |
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| Institution: | WANG Ren-tao,SHE Dan-yang Department of Respiratory Medicine,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To observe the clinical effect of Carbapenems combined with sulbactam on hospital-acquired pheumonia(HAP) caused by carbapenem-resistant Acinetobacter baumannii.Methods Seventeen patients diagnosed with HAP caused carbapenem-resistant Acinetobacter baumannii were treated with carbapenems combined with sulbactam(imipenem and cilastatin sodium 0.5g iv(once 6h) or meropenem 0.5g iv(once 6h)combined with sulbactam 1g iv(once 8h) in our hospital from October 2007 to April 2009.Their clinical features a... |
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| Keywords: | Multidrug Resistant Acinetobacter Baumannii Carbapenem Sulbactam Clinical Features Nosocomial Infection |
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