BMP-2复合PLGA／磷酸三钙修复大段骨缺损的实验研究

目的研究骨形态发生蛋白-2（Bone Morphogenetic Protein，BMP-2）复合聚乳酸一乙醇酸共聚物（P01y-Laetide-CoGlycolic，PLGA）／磷酸三钙（Tricalcium Phosphate，TCP）修复羊大段桡骨缺损的能力。方法手术制成30mm绵羊尺、桡骨骨缺损模型，A组在桡骨缺损区植入BMP-2复合PLGA／磷酸三钙棒材，B组不植入任何材料。两组均以钢板固定桡骨缺损区。术后4、8、12、24周拍摄X片，24周时处死动物进行组织学观察。结果X线片检查示A组术后24周桡骨缺损处完全成骨修复，皮质骨与髓腔的轮廓清晰；B组无有效骨痂形成。组织学检查示A组术后24周时骨痂外层形成皮质骨，为较成熟的板层骨，与断端皮质骨完全融合，其中央可见大量骨髓组织，未见植人材料残留；B组缺损区可见大量纤维组织填充。结论BMP-2复合PLGA/磷酸三钙能很好的修复绵羊大段桡缺损，未来有望成为解决临床骨缺损的有效材料。

Application of compound bone morphogenetic protein 2,polylactide coglycolic acid and tricalcium phosphate in repair of large segmental defects in radius of sheep

Objective To study the application of compound bone morphogenetic protein 2(BMP-2),polylactide coglycolic acid(PLGA) and tricalcium phosphate(TCP) in repair of large segmental defect in radius of sheep.Methods A 30mm-long radius and ulna defect of sheep was established by surgery.Sheep were divided into group A and group B.Sheep in group A underwent implantation of compound BMP-2,PLGA and tricalcium phosphate into their radial defect.Sheep in group B received no implantation of any material into their radia...