Model mis-specification and overestimation of the intraclass correlation coefficient in cluster randomized trials |
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| Authors: | Giraudeau Bruno |
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| Affiliation: | INSERM CIC 202, Faculté de Médecine, Tours, France. giradeau@med.univ-tours.fr |
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| Abstract: | Intraclass correlation coefficient (ICC) estimates must be provided when reporting the results of a cluster randomized trial. This study demonstrates that estimating this parameter with one-way ANOVA and an underlying mixed-effects statistical model leads to biased estimates. The bias depends on the effect size of the studied treatment. |
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| Keywords: | bias cluster randomized trial intraclass correlation coefficient mixed‐effects model one‐way random effects model |
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