| 精芪双参胶囊质量控制方法的改进 |
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| 引用本文： | 吴萍,高嵩,徐建,郑广晶,李亚东,崔宪利.精芪双参胶囊质量控制方法的改进[J].长春中医药大学学报,2018(1):37-39. |
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| 作者姓名： | 吴萍 高嵩 徐建 郑广晶 李亚东 崔宪利 |
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| 作者单位： | 吉林修正药业新药开发有限公司 吉林省中药标准化关键工程技术重点实验室,长春,130103
吉林长白山药业集团股份有限公司,吉林 白山,134300 |
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| 基金项目： | 吉林省"双十工程"重大科技成果转化项目"中药大品种精芪双参胶囊二次开发与产业化" |
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| 摘 要： | 目的改进精芪双参胶囊质量控制方法。方法采用薄层色谱法进行人参鉴别研究;采用高效液相色谱法建立丹参中丹酚酸B含量测定方法。结果改进后人参鉴别薄层色谱中特征斑点分离清晰,阴性无干扰;丹酚酸B在0.2~2μg范围内呈良好的线性关系,加样回收率为99.60%。结论改进的人参薄层色谱鉴别方法及建立的丹酚酸B含量测定方法专属性强,重现性和耐用性好,可用于精芪双参胶囊的质量控制。
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| 关 键 词： | 精芪双参胶囊 薄层色谱鉴别 人参 丹酚酸B 含量测定 Jingqi Shuangshen capsule Thin Layer Chromatography identification ginseng salvianolic acid B content determination |
Improvement of quality control method of Jingqi Shuangshen Capsule |
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| WU Ping,GAO Song,XU Jian,ZHENG Guangjing,LI Yadong,CUI Xianli.Improvement of quality control method of Jingqi Shuangshen Capsule[J].Journal of Changchun College of Traditional Chinese Medicine,2018(1):37-39. |
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| Authors: | WU Ping GAO Song XU Jian ZHENG Guangjing LI Yadong CUI Xianli |
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| Abstract: | Objective To improve the quality control method of Jingqi Shuangshen capsule. Methods The research on ginseng identification by Thin Layer Chromatography and determination of salvianolic acid B in salvia miltiorrhiza by High Performance Liquid Chromatography. Results The characteristic spots in TLC are clear, negative and no interference after improvement; salvianolic acid B in the range of 0.2 μg ~ 2 μg showed a good linear relationship, the recovery rate of 99.60%. Conclusion The improved ginseng TLC identification method and the established method for the content determination of glutamic acid B are excellent, reproducible and durable, which can be used for quality control of Jingqi Shuangshen capsule. |
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