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狼疮性肾炎病理类型与临床表现及实验室指标的相关性
引用本文:严之桢,聂萍,郑旭州,白雪,高竹梅,董长青,吴淋淋,李丽,罗萍. 狼疮性肾炎病理类型与临床表现及实验室指标的相关性[J]. 长春中医药大学学报, 2018, 0(1): 162-165. DOI: 10.13463/j.cnki.cczyy.2018.01.053
作者姓名:严之桢  聂萍  郑旭州  白雪  高竹梅  董长青  吴淋淋  李丽  罗萍
作者单位:吉林大学第二医院肾病内科,长春,130041
摘    要:目的探讨狼疮性肾炎(LN)病理与临床表现及实验室指标的相关性。方法对99例LN患者病理类型、临床表现、实验室指标进行回顾性分析,总结病理类型、临床表现、实验室指标之间的相关性。结果 LN病理类型以Ⅳ+Ⅴ型最为常见,占38.10%,其次为Ⅳ型26.30%,Ⅴ型为16.20%,Ⅱ型最少,占3.03%;临床肾损害主要以肾病综合征型(51.52%)、肾炎综合征型(36.36%)为主。最常见的肾外临床表现为血液系统损伤(80.81%),其次为浆膜炎(56.57%),而神经系统损伤少见(5例)。Ⅳ+Ⅴ型血肌酐最高,Ⅲ+Ⅴ型24 h尿蛋白定量最高,Ⅳ型血红蛋白最低,Ⅱ型24 h尿蛋白定量明显比其他各病理类型低(P0.05)。SLEDAI评分Ⅳ型最高,Ⅱ型最低,且Ⅳ型、Ⅳ+Ⅴ型评分明显高于Ⅱ型(P0.05)。结论狼疮性肾炎的病理类型与临床表现、实验室指标存在一定相关性,肾活检术对于判断肾脏病变程度、活动性,指导进一步诊治及判断预后具有重要意义。

关 键 词:狼疮性肾炎  病理类型  肾活检  Lupus nephritis  pathological type  renal biopsy

Correlation between pathological types,clinical manifestations and laboratory indexes of lupus nephritis
YAN Zhizhen,NIE Ping,ZHENG Xuzhou,BAI Xue,GAO Zhumei,DONG Changqing,WU Linlin,LI Li,LUO Ping. Correlation between pathological types,clinical manifestations and laboratory indexes of lupus nephritis[J]. Journal of Changchun College of Traditional Chinese Medicine, 2018, 0(1): 162-165. DOI: 10.13463/j.cnki.cczyy.2018.01.053
Authors:YAN Zhizhen  NIE Ping  ZHENG Xuzhou  BAI Xue  GAO Zhumei  DONG Changqing  WU Linlin  LI Li  LUO Ping
Abstract:Objective To explore the correlation between pathological types, clinical manifestations and laboratory indexes of lupus nephritis (LN). Methods The pathological types, clinical manifestations and laboratory indexes of 99 patients with LN were analyzed retrospectively, and the correlation between pathological types, clinical manifestations and laboratory indexes was summarized. Results The most common type of pathology was IV + V, accounting for 38.10%, followed by type IV 26.30%, V type 16.20%, and type II least, accounting for 3.03%, nephrotic syndrome (51.52%) and nephritic syndrome type (36.36%) were the main clinical renal damage. The most common clinical manifestations were hematological system damage (80.81%), followed by hydrohymenitis (56.57%), and nervous system injury was rare (5 cases). The serum creatinine was the highest in type IV + V, and the III + V 24 h urinary protein was the highest, type IV hemoglobin was the lowest, and type II 24 h urine protein was significantly lower than the other pathological types (P<0.05). The SLEDAI score was the highest in type IV, the lowest in type II, and the scores of type IV, IV + V were significantly higher than those of type II (P<0.05). Conclusion The pathological types and clinical manifestations, laboratory index of lupus nephritis has certain relevance, renal biopsy is of great significance in judging the degree and activity of renal lesions, guiding further diagnosis and treatment and judging prognosis.
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