黄连素对肾移植患者环孢素A血浓度的影响

目的　研究黄连素对环孢素A（CsA）血浓度的影响。方法　将50例同种异体肾移植术后的患者随机分为2组。1组为黄连素组，30例；另1组为对照组，20例。用黄连素前测定所有受者的CsA血浓度谷值。黄连素用量为0.2g，每日3次,7d后复测所有受者的CsA血浓度值，同时测定肝、肾功能，观察期间免疫抑制剂用量不变，不用其它影响CsA血浓度的药物。结果　服用黄连素后CsA血浓度与服黄连素前相比显著升高，P＜0.001。结论　黄连素可提高CsA血浓度，与CsA联合应用可减少CsA用量。

Effect of berberine on the blood concentration of cyclosporine A in the renal transplant recipients

Objective To investigate the effect of berberine on the blood concentration of cyclosporine A (CsA) in the renal transplant recipients. Methods Fifty cardaveric renal transplant recipients were randomly divided into 2 groups: 30 patients receiving berberine in comparison with other 20 non berberine receiving patients. The dosage of berberine was 0.2 ?g each time, 3 times per day. The blood concentration of CsA was assayed before the patients took berberine. After 7 days of their taking berberine, the blood concentration of CsA, renal and liver function were assayed on the condition that the dosage of CsA was kept constant and no other medicines affecting the concentration of CsA were taken.Results The concentrations of CsA in the 30 berberine receiving patients were apparently increased in comparison with those non berberine receiving ones ( P < 0.001 ). Conclusion The usage of berberine in association with CsA could increase the concentration of blood CsA and reduce the dosage of CsA.