| 神经酰胺与辐射诱导细胞凋亡 |
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| 引用本文： | 李林,史剑慧. 神经酰胺与辐射诱导细胞凋亡[J]. 国际放射医学核医学杂志, 2000, 24(2): 85-89 |
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| 作者姓名： | 李林 史剑慧 |
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| 作者单位： | 200032 上海, 上海医科大学放射医学研究所 |
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| 摘 要： | 神经酰胺作为神经鞘脂类的主要成员之一,是一个主要调节细胞活动的第二信使,以转导细胞凋亡等细胞生长抑制活动信号为主。研究表明,神经酰胺通路不同水平的功能性变化直接影响细胞的药敏感性和辐射敏感性,肿瘤细胞神经酰胺缺陷可导致肿瘤细胞对药物和电射的敏感性下降。
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| 关 键 词： | 神经酰胺 细胞凋亡 辐射敏感性 |
| 收稿时间： | 1999-08-10 |
Ceramide and apoptosis induced by radiation |
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| LI Lin,SHI Jian hui. Ceramide and apoptosis induced by radiation[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2000, 24(2): 85-89 |
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| Authors: | LI Lin SHI Jian hui |
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| Affiliation: | Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032, China |
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| Abstract: | Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities, whose major function is to transmit growth-inhibiting signals including apoptotic.It has been proven by a lot of experimental facts that the changes of the functions at different levels of ceramide signaling pathway directly affect cellular drug sensitivity and radiation sensitivity.In addition, the defective functions of ceramide signaling path in tumor cells may result in the decrease of their drug sensitivity and radiation sensitivity. |
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| Keywords: | ceramide cellular apoptosis radiation sensitivity |
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