398例女性泌尿生殖道衣原体支原体检测及支原体耐药性分析

目的：了解女性泌尿生殖道支原体、沙眼衣原体感染率及生殖道支原体耐药性，为临床合理用药提供参考。方法采用层析胶体金法检测沙眼衣原体抗原，解脲脲原体检测及其药敏试验采用普通培养法。结果398份分泌物中共检出沙眼衣原体阳性20例，解脲脲原体阳性192例，阳性率分别为5．03％和48．24％，解脲脲原体对西环素类敏感率约为80．00％，对喹诺酮类敏感率为14．06％～38．02％，对大环内酯类敏感率为29．69％～89．58％。结论女性泌尿生殖道感染以解脲脲原体为主，且对多种抗菌药物有不同程度的耐药，西环素类可作为治疗解脲脲原体感染首选。

Analysis of detection and susceptibility result for urogenital mycoplasma and chlamydia isolated from 398 female patients

Objective To explore the situation of urogenital mycoplasma and chlamydia infection and drug-resistance in the female patients and provide a reference to rational drug use for clinicians.Methods Chlamydia antigen in clinical specimens were detected by im-munochromatography gold-labeled （MACG）technique and mycoplasma susceptibility was test by culture,respectively.Results In 398 cases of urogenital samples,20 cases were chlamydia trachomatis positive with a positive rate of 5.03%,192 were mycoplasma positive,and the positive ratio was 48.24%.The results of drug sensitivity showed that sensitivity rate to doxycycline was about 80%,and that to quinolones and macrolide antibiotics was 14.06%~38.02%,29.69%-89.58%,respectively.Conclusion Proportions of infection is mainly in female urogenital and genital tract of our county,and it is resistant to most drugs.Doxycycline is the first choice of clinical mycoplasma infection.