新生儿胆红素脑病脑脊液胆红素及脑干听觉诱发电位检测的临床意义

目的探讨新生儿胆红素脑病脑脊液胆红素水平及脑干听觉诱发电位（BAEP）检查的临床意义。方法选取高胆红素血症新生儿为研究对象，分为胆红素脑病组（44例）和非胆红素脑病组（79例），比较两组患儿脑脊液、血清胆红素水平以及BAEP变化。结果胆红素脑病组患儿脑脊液胆红素水平高于非胆红素脑病组[（11.0 ± 3 .9）mol／L VS（7. 4± 4.0）mol/L]，差异有统计学意义（P〈0 .05）；胆红素脑病组BAEP异常发生率（61 4％）高于非胆红素脑病组（16 5％），差异有统计学意义（P〈0 .01）。结论脑脊液胆红素水平检测可作为新生儿胆红素脑病早期诊断的可靠指标，胆红素脑病新生儿早期听觉损伤发生率高，需早期干预治疗。

The clinical significance of cerebrospinal fluid bilirubin and brainstem auditory evoked potential tests in neonatal bilirubin encephalopathy

Objective To explore the clinical significance of cerebrospinal fuid bilirubin level and brainstem auditor7 evoked poten- tial in neonatal bilirubin encephalopathy. Methods All the cases with hyperbilirubinemia were selected from July 2011 to July 2013 in our department, and were divided into the bilirubin encephalopathy group （44 cases） and the non-bilirubin encephalopathy group （79 cases）. Ce- rebrospinal fluid,serum bilirubin level and brainstem auditor7 evoked potential （BAEP） changes were compared between the two groups of children. Results The cerebrospinal fluid bilirubin level in bilirubin encephalopathy group was higher than that of non-bilirubin encephalopa- thy group [ （11.0 ＋ 3.9） tendency/L vs （7.4 ＋ 4.0） tendency/L], and the difference was statistically significant （P 〈 0.01）. The inci- dence of abnormal BAEP （61.4%） in bilirubin encephalopathy group was higher than that of non-bilirubin encephalopathy group （ 16.5% ） , and the difference was statistically significant （P 〈 0.01）. Conclusion Cerebrospinal fluid bilirubin can be used as a reliable indicator for bilirubin encephalopathy in the early diagnosis, and newborn iul＇ants with bilirubin encephalopathy accompanied by higher incidence of hearing damage require early intervention trestlnent.