122株鲍曼不动杆菌的感染分布及耐药性分析

目的对鲍曼不动杆菌在医院感染的分布情况及耐药性进行分析，为临床合理使用抗生素提供参考。方法回顾性分析2007年鲍曼不动杆菌在各病区及标本中的分布，用纸片琼脂扩散法检测抗生素耐药性，并根据美国临床实验室标准化委员会的相关文件进行结果判断。结果122株鲍曼不动杆菌中，痰液分布率最高，为85．25％（104／122），病室中呼吸内科检出率最高，为29．51％（36／122）。耐药率最高的抗生素是头孢西丁、头孢噻肟，分别为85．71％和72．73％。结论鲍曼不动杆菌已经成为呼吸道感染的重要病原菌，尤其是使用机械通气的患者应加强对鲍曼不动杆菌耐药性的连续监测，以便指导临床合理使用抗生素。

Clinical distribution and drug resistance of 122 strains of Acinetobacter baumannii

Objective To investigate the clinical distribution and drug resistance of Acinetobacter baumannii, so as to provide reference for rational use of antibiotics in clinic. Methods The clinical data of Acinetobacter baumannil distribution in different wards and species and drug resistance were retrospectively analyzed in 2007. Paper diffusing method （K-B） was adopted to perform drug resistance test. The results were evaluated according to the relevant documents of NCCLS. Results In all species, sputum had the highest isolating rate （85.25 % ） ; in different wards, respiratory medical department topmost （29.51%）. The antibiotics with highest resistant rate of Acinetobacter baumannii were cefoxitin （85.71%） and cefotaxime （72.73 N）. Conclusion Acinetobacter baumannii has been an important pathogenic bacterium. Especially for patients receiving mechanical ventilation therapy, continuous monitoring of drug resistance should be strengthened so as to guide the rational use of antibiotics in clinic.