| 一氧化氮肝脏保护作用与氧自由基的关系 |
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| 引用本文： | 孙克勤,李素芝,刘厚东,王茂旭,姜力.一氧化氮肝脏保护作用与氧自由基的关系[J].高原医学杂志,2003,13(2):26-27. |
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| 作者姓名： | 孙克勤 李素芝 刘厚东 王茂旭 姜力 |
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| 作者单位： | 西藏军区总医院病理科,拉萨,850003 |
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| 摘 要： | 目的探讨内源性一氧化氮(NO)对大鼠肝缺血再灌注损伤的作用及其与脂质过氧化的关系;方法以缺血再灌注制成大鼠模型,以工具药L-精氨酸(L-arg)为外源性NO的激动剂,观察内源性NO对肝脏损伤程度和脂质过氧化终产物丙二醛(MDA)含量的影响;结果缺血再灌注可造成肝组织损伤,MDA含量增加,内源性NO水平降低,与对照组比较(P＜0.01).以L-arg激动内源性NO,可明显减轻肝组织损伤程度,同时MDA含量降低,NO水平升高,与IR组比较(P＜O.05);结论内源性NO具有肝脏保护作用,其保护机制可能与抗氧自由基有关.
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| 关 键 词： | 一氧化氮 缺血再灌注 肝脏 丙二醛 |
THE PROTECTIVE EFFECT AND MECHANISM OF NITRIC OXIDE ON ISCHEMIC LIVER |
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| Sun Keqin,Li Suzhi,Liu Houdong,Wang Maoxu,Jiang Li The General Hospital of Xi zang Military Command Lasa.THE PROTECTIVE EFFECT AND MECHANISM OF NITRIC OXIDE ON ISCHEMIC LIVER[J].Journal of High Altitude Medicine,2003,13(2):26-27. |
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| Authors: | Sun Keqin Li Suzhi Liu Houdong Wang Maoxu Jiang Li The General Hospital of Xi zang Military Command Lasa |
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| Abstract: | Objective:To investigate the effect of endogenous nitric oxide (NO) on liver with ischemic reperfusion in rats and the relationship between the effect and lipid peroxidaton.Methods:The injury liver model in the rats was induced by ischemic reperfusion.The endogenous NO was activated using the L-arginine (L-arg) activator in the models.To observe the protective effect of the NO on liver and to measure the serum level of MDA for evaluated the relationship.Results:The level of MDA was increased and the level of endogenous NO was decreased in model compared with that in controls (P< 0.01).The level of endogenous NO was increased and the level of serum MDA was decreased by L-arg.Conclusion:The endogenouse NO protects the liver from ischmic injury. The protective effect could associate with against oxide. |
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| Keywords: | Nitric oxide Ischemic reperfusion Liver Malonaldehyde Rats Animal model |
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