DPC4蛋白在胆道恶性肿瘤中的缺失表达 |
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摘 要: |
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关 键 词: | DPC4蛋白 胆道恶性肿瘤 部位 免疫组化 DPC4基因 缺失表达频率 |
收稿时间: | 8 November 2001 |
Frequency of loss expression of DPC4 protein in various locations of biliary tract carcinoma |
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Authors: | Zhaohui Tang Shengquan Zou Youhua Hao Baoju Wang Xiangping Yang Fazu Qiu |
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Institution: | (1) Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China;(2) Institute of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;(3) Department of Biochemistry, Rheinisch-Westfalische Technische Hochschule (RWTH), D-52074 Aachen, Germany |
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Abstract: | Objective To clarify the relationship between loss of expression of DPC4 proteins and pathogenesis of biliary tract carcinoma.
Methods 71 primary biliary tract carcinomas (BTCa), including 38 common bile duct (CBD) carcinomas, 18 gallbladder carcinomas, and
15 hilar bile ducts (HBD) carcinomas were examined by immunohistochemical staining. In addition, the CBD carcinomas were divided
into two groups, a tumor group with metastasis (M+ group, 27 cases) and a tumor group without metastasis (M− group, 11 cases).
Results The frequency of loss expression of DPC4 protein was 32.8% in BTCa, 47.3% in CBD carcinoma, 11% in gallbladder carcinoma and
13% in HBD carcinoma. A comparison of the frequency of loss expression of DPC4 showed significantly statistical difference
in the CBD carcinoma versus gallbladder carcinoma and HBD carcinoma (P<0.01). The frequency of loss expression of DPC4 was 48.1% in the M+ group and 45.4% in the M− group. There was no significantly statistical difference between them (P>0.05).
Conclusion There is a close relationship between the pathogenesis of BTCa and inactivation of DPC4 with different frequencies of DPC4
gene alteration in various locations of the biliary tract, but inactivation of DPC4 is not related with tumor metastasis in
BTCa. |
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Keywords: | DPC4 gene immunohistochemistry biliary tract carcinoma |
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