| 华南地区IDDM易感性与HLA DQA1第52位精氨酸相关性的探讨 |
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| 引用本文： | 张莹,程桦.华南地区IDDM易感性与HLA DQA1第52位精氨酸相关性的探讨[J].中华内分泌代谢杂志,1996,12(2):74-77. |
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| 作者姓名： | 张莹 程桦 |
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| 作者单位： | 中山医科大学附属孙逸仙纪念医院，中山医科大学附属孙逸仙纪念医院，中山医科大学附属孙逸仙纪念医院，中山医科大学中心实验室分子生物室，中山医科大学遗传教研室，中山医科大学附属孙逸仙纪念医院 510120广州，510120广州，510120广州，510120广州 |
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| 摘 要： | 采用４个序列特异的寡核苷酸探针检测了４０例华南地区汉族ＩＤＤＭ患者（包括１４岁前发病者８例，１５￣３０岁发病者１９例，３１岁后发病者１３例）及５１例华南地区汉族对照的ＨＬＡ ＤＱＡ１基因。结果显示：１４岁前发病ＩＤＤＭ组ＤＱＡ１５２Ａｒｇ（＋）频率显著高于对照组、１５￣３０岁发病组和３１岁后发病组；ＤＱＡ１５２Ａｒｇ（＋）／Ａｒｇ（＋）／Ａｒｇ（＋）及ＤＱＡ１１ ０３０１频率越高，Ａｒｇ（＋）／Ａ
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| 关 键 词： | 精氨酸 糖尿病 人白细胞抗原 |
THE ASSOCIATION OF HLA DQA_1 52 ARGININE ( ) WITH IDDM SUSCEPTIBILITY IN A |
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| Zhang Ying,Cheng Hua,Fu Zu-zhi,et al..THE ASSOCIATION OF HLA DQA_1 52 ARGININE ( ) WITH IDDM SUSCEPTIBILITY IN A[J].Chinese Journal of Endocrinology and Metabolism,1996,12(2):74-77. |
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| Authors: | Zhang Ying Cheng Hua Fu Zu-zhi |
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| Institution: | Zhang Ying,Cheng Hua,Fu Zu-zhi,et al. Department of Endocrinology,Sun Yat-sen Memorial Hospital,Guangzhou 510120 |
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| Abstract: | The HLA DQA1 genes of 40 IDDM patients (including 8 cases with onset of diabetes before 14 years of age, 19 between 15-30 years and 13 after 31 years) and 51 healthy controls were studied by using for allele specific oligonucleotide probes. All of our research subjects are of Southern Chinese origin. The results showed that the HLA DQA1 52Arg( ) associated IDDM susceptibility is significantly higher in the group younger than 14 years of age (P<0. 05, RR=5. 98). Among IDDM patients , the younger the age of onset the higher the frequencies of HLA DQA1 52Arg( ) , Arg( )/Arg ( ) homozygote and DQA1 0301 genotype and the lower the frequencies of DQA1 Arg( )/Arg(-) heterozygote. Strong predisposing factors like DQA1 52Arg ( ) and / or other susceptibility genes linked to HLA DQA1 52Arg( ) may trigger an earlier disease in life. The genetic susceptibility of those with late onset of the disease may mainly relate to genes other than HLA DQA1 52Arg( ). In addition, the genetic basis between early and late onset IDDM patients may be different. |
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| Keywords: | IDDM DQA1 52Arginine |
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