| 过敏性紫癜患儿外周血CD40L mRNA表达及其与血清IL-6和IL-8的关系 |
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| 引用本文： | 李燕林,封其华,王永清,胡国成.过敏性紫癜患儿外周血CD40L mRNA表达及其与血清IL-6和IL-8的关系[J].临床儿科杂志,2009,27(10). |
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| 作者姓名： | 李燕林 封其华 王永清 胡国成 |
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| 作者单位： | 1. 常州市第一人民医院,苏州大学附属第三医院儿科,江苏常州,213000
2. 苏州大学附属儿童医院,江苏苏州,215000 |
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| 摘 要： | 目的 探讨过敏性紫癜患儿外周血单个核细胞(PBMC)中CD40L mRNA的表达及其与血清中IL-6和IL-8的关系.方法 应用逆转录一聚合酶链式反应(RT-PCR),从转录水平检测30例过敏性紫癜(HSP)患儿和20例正常儿童(对照组)PBMC中CD40L mRNA的表达,并应用ELISA双抗体夹心法检测血清中细胞因子IL-6和IL-8的水平.结果 HSP患儿(PBMC)中CD4JDL mRNA的表达明显高于对照组(P<0.05);HSP患儿血清中IL-6和IL-8水平明显高于对照组(P<0.05),加入抗-CD40L mAb后恢复正常.结论 HSP患儿PBMC中CD40L的表达异常增高,且CD40L的表达与血清中IL-6和IL-8呈正相关.
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| 关 键 词： | 过敏性紫癜 |
Expression of CD40L mRNA in peripheral blood mononuclear cells of patients with HSP and its relation with IL-6 and IL-8 in serum |
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| LI Yan-lin,FENG Qi-hua,WANG Yong-qing,HU Guo-cheng.Expression of CD40L mRNA in peripheral blood mononuclear cells of patients with HSP and its relation with IL-6 and IL-8 in serum[J].The Journal of Clinical Pediatrics,2009,27(10). |
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| Authors: | LI Yan-lin FENG Qi-hua WANG Yong-qing HU Guo-cheng |
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| Institution: | 1.Department of Pediatrics;The First People's Hospital of Changzhou;The Third Hospital Affiliated to Soochow University;Changzhou 213000;Jiangsu;China;2.The Pediatric Hospital Affiliated to Soochow University;Suzhou 215000;China |
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| Abstract: | |
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| Keywords: | CD40L IL-6 IL-8 |
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