Composite germ cell tumor and B-cell non-Hodgkin's lymphoma arising in the sella turcica |
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Authors: | Valdez Riccardo McKeever Paul Finn William G Gebarski Stephen Schnitzer Bertram |
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Affiliation: | Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109, USA. |
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Abstract: | We report the case of a composite malignant neoplasm consisting of germ cell tumor and B-cell non-Hodgkin's lymphoma occurring in the sella turcica of a young girl who presented with hypopituitarism. Routine hematoxylin and eosin-stained sections of a resected suprasellar tumor demonstrated a neoplasm composed of 2 distinct morphologies. A panel of immunohistochemical markers was used to confirm the morphologic impression of germinoma (cytokeratin AE1/AE3-CAM 5.2, cytokeratin 7, neuron-specific enolase, and focally placental alkaline phosphatase positive) and mature B-cell lymphoma (CD20 positive; pancytokeratin, placental alkaline phosphatase, and terminal deoxynucleotidyl transferase negative). To the best of our knowledge, this is the first reported case of such a composite tumor in the central nervous system. |
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