| 川芎嗪在兔体内代谢产物的研究 |
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| 引用本文： | 陈欣,董善年. 川芎嗪在兔体内代谢产物的研究[J]. 药学学报, 1996, 31(8): 617-621 |
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| 作者姓名： | 陈欣 董善年 |
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| 作者单位： | 北京医科大学药学院 |
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| 摘 要： | 应用高效液相色谱法将川芎嗪在家兔血液中的代谢产物进行分离,对原药及两种代谢产物进行了紫外、红外、质谱、核磁共振等光谱分析,推断出川芎嗪代谢产物的结构,并用化学方法合成了代谢物对照品,对其结构进一步得到验证。
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| 关 键 词： | 川芎嗪 代谢产物 高效液相色谱法 |
| 收稿时间： | 1995-08-21 |
STUDIES ON THE METABOLITES OF TETRAMETHYLPYRAZINE IN RABBITS |
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| X Chen and SN Dong. STUDIES ON THE METABOLITES OF TETRAMETHYLPYRAZINE IN RABBITS[J]. Acta pharmaceutica Sinica, 1996, 31(8): 617-621 |
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| Authors: | X Chen and SN Dong |
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| Abstract: | The metabolites of tetramethylpyrazine in rabbit have been separated by HPLC and solvent extraction. Their structures were identified by means of UV, IR, MS and NMR spectroscopy. The possible metabolic ways of TMPz are oxidization of one of the four methyl groups to hydroxymethyl and carboxyl group forming 2 hydroxymethyl 3,5,6 trimethylpyrazineand 3,5,6 trimethylpyrazine 2 carboxylic acid . These were further confirmed by the identity of HPLC data and all the above spectral parameters of the metabolites in vivo and the compounds objectively synthesized from TMPz. |
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| Keywords: | Tetramethylpyrazine Metabolites HPLC |
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