多囊卵巢综合征患病相关因素初步研究

目的:探讨多囊卵巢综合征(PCOS)患病相关风险因素。方法:对PCOS患者47例以及同期作为对照的月经规律的患者42例进行临床体征评分、内分泌指标测定,采用调查问卷法搜集其家族史等发病相关因素,采用病例对照研究进行分析。结果:①PCOS组患者家族中糖尿病(DM)及女性月经失调(闭经或月经稀发)的患病率大于对照组(P=0.000),二组家族中男性秃顶的患病率差异无统计学意义(P>0.05);②PCOS患者出生体重(birth weight,BW)低于对照组(P=0.000);③PCOS患者24h摄入食物能量大于对照组(P<0.05);④两组之间初潮时间、运动情况等的差异无统计学意义(P>0.05)。结论:肥胖、低出生体重及月经紊乱的家族史均为PCOS发病的独立危险因素,糖尿病家族史可能与PCOS发病有关,提示了家族遗传、BW及出生后的饮食状况都可能是PCOS发病的主要影响因素。

Analysis of related prevalent factors in polycystic ovary syndrome

Objective： To analyze the related prevalent factors in polycystic ovary syndrome（PCOS）. Methods： A cross-sectional study were performed the data of the anthropometric measurements, clinical manifestations of hyperandrogenism and hyperinsulinism, serum levels of LH, FSH, E2,T, PRL and factors like birth weight（BW）, family history and moreover dietary intake in the whole 24 h were collected from 47 women with PCOS aged 25.4 ± 4.4 years and 42 age matched bilateral tubal block factor infertile women served as the control. ResuLts： （1） The family prevalence of diabetes mellitus （DM） and menstrual disorder （amenorrhea or oligomenorrhea） was higher in PCOS group than in the control （P=0.000）, and that of alopecia was not statistical significant （P〉0.05）. （2） BW was lower in PCOS group than in the control （P=0.000）. （3） The total energy intake was higher in PCOS group than in the control （P〈0.05）. （4） Age of menarche and amount of exercise were not statistical significant （P〉0.05）. Conclusion： Each of obesity, low birth weight and family history of menstrual disorder was an independent risk factor for PCOS and family history of DM might be effective to PCOS, which implied that familial inheritance, BW and postnatal dietary intake all contributed to the prevalence of PCOS.