Human scalp irritation compared to that of the arm and back |
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Authors: | Zhai Hongbo Fautz Rolf Fuchs Anne Bhandarkar Sulochana Maibach Howard I |
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Affiliation: | Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143-0989, USA. |
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Abstract: | Large-scale data comparing reactions to surfactants between scalp and back and arm are lacking. The sensitivity of responses between scalp and back and arm were explored utilizing an open-application model for testing the potential irritancy of sodium lauryl sulphate (SLS). 10 bald male Caucasians (mean age 56 +/- 9 years) were enrolled. We conducted 5 successive washings: for each wash, the technician pipetted 1 ml of 20% SLS solution into a glass cylinder placed on the designated area with hand pressure that prevented the cylinder leaking. The test area was then rubbed with a Teflon Policeman scrubber for 1 min. Post scrubbing, the solution was absorbed dry with a plastic pipette and blotted by gently applying paper tissues. After a 5-min rest, the procedure was repeated for 4 more times for a total of 5 times. Skin-irritancy assessments by visual scoring and instrumental measurements were made at 30 min and 24 h thereafter and squamometry at the end of last washing. Results indicated that most param- eters revealed that the back was most sensitive to the SLS challenge. Thus, these data support the current standard skin-compatibility testing procedure, employing the back for potential irritation testing of hair care products. |
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Keywords: | hair care products intercorneocyte cohesion sodium lauryl sulphate (SLS) squamometry transepidermal water loss (TEWL) |
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