金芪降糖片治疗多囊卵巢综合征的临床研究

目的观察金芪降糖片治疗多囊卵巢综合征肥胖患者的临床疗效。方法对24例多囊卵巢综合征肥胖患者给予口服中药金芪降糖片治疗3个月,观察治疗前后的临床疗效和生化指标,包括月经、肥胖和性激素值测定,进行口服葡萄糖耐量试验评估糖代谢变化和绒毛膜促性腺激素兴奋卵巢试验评估雄激素合成。结果与治疗前比较,治疗后体质量指数下降(P<0.05);葡萄糖耐量试验30min的血糖下降(P<0.05),绒毛膜促性腺激素兴奋卵巢试验后18h睾酮水平下降(P<0.05)。在完成试验的16例患者中,9例月经改善,1例伴氯米芬耐药者再用氯米芬获得妊娠。结论金芪降糖片对多囊卵巢综合征的临床疗效可能与该复方调节糖代谢和雄激素合成有关。

Therapeutic effects of Jinqi Jiangtang Tablet on women with polycystic ovary syndrome

Objective: To observe the therapeutic effects of Jinqi Jiangtang Tablet (JQJTT), a commonly prescribed recipe for type 2 diabetes in traditional Chinese medicine, on obese women with polycystic ovary syndrome (PCOS). Methods: Twenty-four obese women with PCOS were prescribed JQJTT for 3 months and the changes of carbohydrate metabolism and biochemical indicators, including menstrual cycle, body mass index (BMI), the level of blood sex hormone, area under curve (AUC) of glucose and insulin during oral glucose tolerance test (OGTT), and testosterone responses during human chorionic gonadotrophin stimulation ovary test were observed. Results: After treatment, there were significantly reductions in BMI (P<0.05), serum glucose level at 30 min during OGTT (P<0.05) and testosterone levels at eighteen hours during human chorionic gonadotrophin stimulation ovary test (P<0.05). In addition, nine patients had improved cycles among sixteen completed patients, and one patient with clomifene resistance got pregnant with response to clomifene treatment. Conclusion: The beneficial effects of JQJTT may result from improvement of carbohydrate metabolism and reduction in androgen biosynthesis in women with PCOS.