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| 祖师麻止痛喷雾剂对豚鼠的长期毒性研究 | |
| 引用本文： | 赵兴红,何家田,涂宏海,张建春,丁永刚. 祖师麻止痛喷雾剂对豚鼠的长期毒性研究[J]. 中国药师, 2011, 14(10): 1440-1443 |
| 作者姓名： | 赵兴红 何家田 涂宏海 张建春 丁永刚 |
| 作者单位： | 1. 兰州军区药品仪器检验所 兰州730050 2. 新疆军区药品仪器检验所 3. 解放军第一医院 4. 兰州大学第二医院 |
| 基金项目： | 军队十一五科研基金面上课题 |
| 摘 要： | 目的:观察祖师麻止痛喷雾剂对豚鼠的长期毒性,为临床安全用药提供依据。方法:将50只豚鼠随机分为空白对照组、高剂量完整皮肤组、高剂量破损皮肤组、低剂量完整皮肤组、低剂量破损皮肤组,连续给药4周。随时观察记录其一般情况,用药后做血液学及血液生化指标检查,计算脏器系数并进行组织病理学检查。结果:祖师麻止痛喷雾剂各剂量组未见毒性反应,与空白对照组比较差异均无统计学意义(P>0.05),停药后也未见药物延迟性毒性反应。结论:长期给予豚鼠祖师麻止痛喷雾剂无明显毒性,推论临床拟用剂量安全。 |
| 关 键 词： | 祖师麻止痛喷雾剂 豚鼠 长期毒性实验 |
Studies on Long-term Toxicity of Zushima Zhitong Spray in Guinea Pigs |
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| Zhao Xinghong,He Jiatian,Tu Honghai,Zhang Jianchun,Ding Yonggang. Studies on Long-term Toxicity of Zushima Zhitong Spray in Guinea Pigs[J]. China Pharmacist, 2011, 14(10): 1440-1443 | |
| Authors: | Zhao Xinghong He Jiatian Tu Honghai Zhang Jianchun Ding Yonggang |
| Affiliation: | Zhao Xinghong~1,He Jiatian~1,Tu Honghai~2,Zhang Jianchun~3,Ding Yonggang(1.Institute for Drug Control of Lanzhou Military Region,Lanzhou 730050,China,2.Institute for Drug Control of Xinjiang Military Region,3.The First Hospital of PLA,4.The Second Hospital of Lanzhou University) |
| Abstract: | Objective:To study the long-term toxicity of Zushima Zhitong spray in guinea pigs and provide data for the clinical administration. Method:Fifty guinea pigs were randomly divided into 5 groups:control group,high-dose group of intact skin,high-dose group of damaged skin,low-dose group of intact skin and low-dose group of damaged skin.The last four groups were treated with drug for consecutive 4 weeks.The general conditions of guinea pigs were observed at any time.The blood analysis and biochemical examinatio... |
| Keywords: | Zushima Zhitong spray Guinea pigs Long-term toxicity test |
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