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| 槲皮素抑制诱导型一氧化氮合酶减轻脓毒症大鼠的心肌损伤 | |
| 引用本文： | 张弛,黄靓,屈顺林,唐志晗,韦星. 槲皮素抑制诱导型一氧化氮合酶减轻脓毒症大鼠的心肌损伤[J]. 中国药理学通报, 2011, 27(11): 1586-1589. DOI: 10.3969/j.issn.1001-1978.2011.11.026 |
| 作者姓名： | 张弛 黄靓 屈顺林 唐志晗 韦星 |
| 作者单位： | 1. 南华大学,心血管病研究所,湖南,衡阳,421001;南华大学,机能学实验中心,湖南,衡阳,421001 2. 南华大学,心血管病研究所,湖南,衡阳,421001;南华大学,外科学总论教研室,湖南,衡阳,421001 3. 南华大学,心血管病研究所,湖南,衡阳,421001 |
| 基金项目： | 湖南省科技计划项目，湖南省高等学校科学研究项目 |
| 摘 要： | 目的初步探讨槲皮素对脓毒症心肌损伤的影响及其机制。方法将30只SPF级♂SD大鼠分为槲皮素预处理组、脓毒症组和假手术组,每组10只。采用盲肠结扎穿刺法制备脓毒症大鼠模型。盲肠结扎穿刺术后12 h经右颈总动脉左心室内插管监测各组大鼠MAP、LVSP、LVEDP、±dp/dtmax等血流动力学指标,免疫印迹法测定心肌组织iNOS蛋白表达,酶法测定心肌组织匀浆中iNOS活力及NO含量。结果脓毒症组大鼠LVSP降低、LVEDP升高、+dp/dtmax与-dp/dtmax均有所下降,而槲皮素预处理组以上各项指标均有不同程度改善;脓毒症组大鼠左心室心肌组织iNOS的表达上调,iNOS的活力升高,NO的含量增加,而槲皮素预处理组以上指标的增加幅度较小。结论槲皮素通过降低心肌组织iNOS的表达及活力,抑制脓毒症时心肌组织中过量的NO产生,减轻脓毒症心肌损伤。 |
| 关 键 词： | 槲皮素 脓毒症 心肌损伤 血流动力学 诱导型一氧化氮合酶 一氧化氮 |
Quercetin inhibits inducible NO synthase overexpression against sepsis-induced myocardial depression |
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| ZHANG Chi,HUANG Liang,QU Shun-lin,TANG Zhi-han,WEI Xing. Quercetin inhibits inducible NO synthase overexpression against sepsis-induced myocardial depression[J]. Chinese Pharmacological Bulletin, 2011, 27(11): 1586-1589. DOI: 10.3969/j.issn.1001-1978.2011.11.026 | |
| Authors: | ZHANG Chi HUANG Liang QU Shun-lin TANG Zhi-han WEI Xing |
| Affiliation: | ZHANG Chi1,2,HUANG Liang1,3,QU Shun-lin1,TANG Zhi-han1,WEI Xing1(1.Institute of Cardiovascular Disease,2.Function Laboratory Center,3.Dept of Operative Surgery,University of South China,Hengyang Hunan 421001,China) |
| Abstract: | Aim To investigate the protective effects of quercetin(QCT) treatment on sepsis-induced myocardial depression and explore its mechanism.Methods Male Sprague-Dawley rats were randomized to 1 of 3 treatments: sham operation group,CLP group and CLP pretreatment with QCT(10 rats in each group).Rat sepsis was created by cecal ligation puncture(CLP) operation.Left ventricular(LV) performance was measured at 12 hours following CLP operation by cardiac hemodynamic measurements via a catheter placed through right co... |
| Keywords: | quercetin sepsis myocardial depression hemodynamics inducible nitric oxide synthase nitric oxide |
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