| 黄芩苷抑制鱼藤酮帕金森病大鼠黑质铁积聚及作用机制 |
| |
| 引用本文： | 宋扬文,陈忻,张楠,郭春彦,熊珮,穆阳. 黄芩苷抑制鱼藤酮帕金森病大鼠黑质铁积聚及作用机制[J]. 中国药理学通报, 2011, 27(12): 1740-1744. DOI: 10.3969/j.issn.1001-1978.2011.12.026 |
| |
| 作者姓名： | 宋扬文 陈忻 张楠 郭春彦 熊珮 穆阳 |
| |
| 作者单位： | 首都医科大学中医药学院中药药理学教研室,北京,100069 |
| |
| 基金项目： | 北京市教委科技发展计划资助项目 |
| |
| 摘 要： | 目的研究PD大鼠中脑黑质多巴胺(DA)神经损伤、铁积聚、铁转运蛋白表达及氧应激水平改变之间的关系,探讨铁积聚在PD发生发展中的作用及黄芩苷保护DA能神经、抑制铁积聚的机制。方法实验采用鱼藤酮PD模型大鼠,观察黑质铁含量及TH、DMT1、FP1的表达,检测血清、肝脏铁含量以及大脑皮层GSH和MDA含量。结果鱼藤酮PD大鼠DA能神经元明显缺失,同步发生了脑内氧化应激水平增加、GSH降低;血清铁降低而肝铁增高;黑质铁大量积聚发生在DA能神经元大量脱失和铁转运蛋白DMT1、FP1表达改变之后;黄芩苷可调节DMT1、FP1表达,减少黑质铁积聚,降低脑内氧应激水平,增加GSH含量。结论研究证明铁转运蛋白DMT1表达增加和FP1表达降低参与了黑质铁积聚;铁积聚及过高的氧应激反应促进了黑质DA能神经细胞损伤的发展;黄芩苷对PD大鼠DA能神经细胞具有保护作用,机制与抑制铁积聚、调节铁转运蛋白DMT1、FP1表达、降低氧应激有关。
|
| 关 键 词： | 帕金森病 鱼藤酮 黄芩苷 铁 二价金属离子转运蛋白1 膜铁转运蛋白1 酪氨酸羟化酶 |
Inhibition on iron deposition in SN in PD rats by baicalin and its mechanism |
| |
| SONG Yang-wen,CHEN Xin,ZHANG Nan,GUO Chun-yan,XIONG Pei,MU Yang. Inhibition on iron deposition in SN in PD rats by baicalin and its mechanism[J]. Chinese Pharmacological Bulletin, 2011, 27(12): 1740-1744. DOI: 10.3969/j.issn.1001-1978.2011.12.026 |
| |
| Authors: | SONG Yang-wen CHEN Xin ZHANG Nan GUO Chun-yan XIONG Pei MU Yang |
| |
| Affiliation: | SONG Yang-wen,CHEN Xin,ZHANG Nan,GUO Chun-yan,XIONG Pei,MU Yang(Dept of Pharmacology of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China) |
| |
| Abstract: | Aim To investigate the relationship between dopaminergic neuronal damage,iron accumulation,expression of iron transporters in SN,and oxidative stress in brain of PD rats to explore mechanism of protection on dopaminergic neurons and inhibition on iron deposition by baicalin.Methods Expressions of TH,DMT1 and FP1,iron content,glutathione(GSH) and malondialdehyde(MDA) in PD rats were detected.Results There was a massive loss of dopaminergic neurons in SN of PD rats,concomitant with increased oxidative stress ... |
| |
| Keywords: | Parkinson's disease rotenone baicalin iron divalent metal transporter 1 ferroportin1 TH |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
