| mTOR信号通路与神经退行性疾病研究进展 |
| |
| 引用本文： | 吴苗苗,苑玉和,陈乃宏.mTOR信号通路与神经退行性疾病研究进展[J].中国药理学通报,2011,27(11):1481-1483. |
| |
| 作者姓名： | 吴苗苗 苑玉和 陈乃宏 |
| |
| 作者单位： | 1. 中国医学科学院药物研究所,北京,100050;天津中医药大学研究生院,天津,300193
2. 中国医学科学院药物研究所,北京,100050 |
| |
| 基金项目： | 国家自然科学基金，国家创新药物重大专项资助项目，国家自然科学基金广东自然科学联合基金 |
| |
| 摘 要： | 哺乳动物雷帕霉素靶蛋白(mammalian target of rapamy-cin,mTOR)是进化上十分保守的丝氨酸/苏氨酸蛋白激酶,是自噬的关键调节位点。自噬体是神经退行性疾病内某些聚集蛋白清除的主要途径之一,近年的研究显示,神经退行性疾病如阿尔采末病、帕金森病、亨廷顿病等疾病模型或患者表现出mTOR通路异常,伴随着自噬功能的紊乱,而抑制mTOR的活性可以正向调节自噬。该文对当前mTOR信号转导通路与神经退行性疾病的研究进行综述。
|
| 关 键 词： | 哺乳动物雷帕霉素靶蛋白 神经退行性疾病 自噬 阿尔采末病 帕金森病 亨廷顿病 |
Research progress on the mTOR signaling pathway and neurodegenerative disease |
| |
| WU Miao-miao,YUAN Yu-he,CHEN Nai-hong.Research progress on the mTOR signaling pathway and neurodegenerative disease[J].Chinese Pharmacological Bulletin,2011,27(11):1481-1483. |
| |
| Authors: | WU Miao-miao YUAN Yu-he CHEN Nai-hong |
| |
| Institution: | WU Miao-miao1,2,YUAN Yu-he1,CHEN Nai-hong1(1.Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050,China,2.Tianjin University of Traditional Chinese Medicine Graduate School,Tianjin 300193,China) |
| |
| Abstract: | It is well known that there are a lot of aggregation of pathological proteins in neurodegenerative diseases,such as senile plaques in Alzheimers disease,lewy bodies in Parkinson's disease,and so on.They could be deared through autophagy.Mammalian target of rapamycin(mTOR),a conserved serine/threonine kinase,Which plays a very important role in the clearance of these pathological products,is a key regulatory factor of autophagy.Growing evidences have shown that there is damaged mTOR signaling pathway in the neurodegenerative diseases.The article is to review the role of mTOR signal in the neurodegenerative diseases. |
| |
| Keywords: | mammalian target of rapamycin neurodegenerative disease autophagy Alzheimer′s disease Parkinson′s disease Huntington′s disease |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
