| 泮托拉唑钠冻干粉针剂生产工艺考察 |
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| 引用本文： | 吴彩萍.泮托拉唑钠冻干粉针剂生产工艺考察[J].中国药师,2011,14(11):1600-1601. |
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| 作者姓名： | 吴彩萍 |
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| 作者单位： | 浙江普洛康裕制药有限公司,浙江东阳,322118 |
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| 摘 要： | 目的:探讨泮托拉唑钠冻干粉针剂的生产工艺研究。方法:通过调节pH及加入适当比例的依地酸二钠(EDTA-2Na)使泮托拉唑钠冻干粉针达到良好的物理性质。结果:加入0.2%EDTA-2Na及配制好的泮托拉唑钠药液pH调到10.8～11,制成的粉针剂外观及溶液稳定性良好。结论:该方法较好地解决了泮托拉唑钠冻干粉针剂生产过程中出现的问题。
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| 关 键 词： | 泮托拉唑钠 冻干粉针剂 生产工艺 |
Study on Improved Preparation Technique of Pantoprazole Sodium Freeze-dried Powder Injections |
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| Wu Caiping.Study on Improved Preparation Technique of Pantoprazole Sodium Freeze-dried Powder Injections[J].China Pharmacist,2011,14(11):1600-1601. |
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| Authors: | Wu Caiping |
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| Institution: | Wu Caiping (Zhejiang Apeloa Kangyu Pharmaceutical Co. Ltd. ,Zhejiang Dongyang 322118, China) |
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| Abstract: | Objective： To explore the improved preparation methods of pantoprazole sodium freeze-dried powder injections. Method ： Adjusting pH and adding appropriate proportion of EDTA-2Na were employed to improve the physical properties of pantoprazole so- dium freeze-dried powder injections. Result： When the pH was 10. 8-11 and the concentration of EDTA-2Na was 0. 2% , the freeze- dried powder showed better appearance and stability in solution. Conclusion： Both of the two methods can solve the problems in prepar- ing pantoprazole sodium freeze-dried powder injections. |
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| Keywords: | Pantoprazole Freeze-dried powder injections Preparation process |
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