| 黄芩提取物对红细胞抗氧化作用研究 |
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| 引用本文： | 张玲莉,邱振鹏.黄芩提取物对红细胞抗氧化作用研究[J].中国药师,2011,14(11):1572-1575. |
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| 作者姓名： | 张玲莉 邱振鹏 |
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| 作者单位： | 1. 武汉大学人民医院药学部,武汉,430060
2. 武汉大学基础医学院,武汉,430060 |
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| 摘 要： | 目的：考察黄芩提取物（SBG）对H2O2所致正常人红细胞（RBCs）氧化的保护作用。方法：将RBCs用黄芩提取物SBG预孵育，经H2O2处理后对红细胞溶血作用、脂质过氧化（MDA）、ROS及met—Hb含量进行分析。结果：含有指标成分黄芩苷的SBG对H2O2致红细胞损伤致氧化应激溶血率、MDA、ROS及met—Hb含量均具有改善作用，不同SBG中黄芩苷含量较低时改善作用相对较弱。讨论：SBG中的黄酮类化合物具有潜在的抗氧化活性，且黄芩提取物可能对人体血液系统氧化应激具有改善作用。
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| 关 键 词： | 黄芩 抗氧化 红细胞 |
Antioxidant Activitv of Extracts from Scutellaria Baicalensis Georgi.towards Normal Human Erythrocytes |
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| Zhang Lingli,Qiu Zhenpeng.Antioxidant Activitv of Extracts from Scutellaria Baicalensis Georgi.towards Normal Human Erythrocytes[J].China Pharmacist,2011,14(11):1572-1575. |
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| Authors: | Zhang Lingli Qiu Zhenpeng |
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| Institution: | 1. Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China; 2. School of Basie Medieal Scienee,Wuhan University) |
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| Abstract: | Objective： To investigate the protective effect of extracts from Scutellaria Baicalensis Georgi. （SBG） towards hydrogen peroxide （H2O2 ）-induced oxidation in normal human erythrocytes （RBCs）. Method： RBCs, pretreated with SBG and challenged with H2O2,were analyzed by the studies of hemolysis,lipid peroxidation, reactive oxygen species （ROS） and methemoglobin production. Re- sult： The oxidative indices were all decreased by incubating the RBCs with SBG which contained baicalin, a kind of marker components in SBG, and the effects depended on the concentration of baicalin. Conclusion： The findings demonstrate that the flavones in SBG show potent antioxidant properties which have beneficial effect in oxidative stress in human blood system. |
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| Keywords: | Radix Scutellariae Baicalensis Antioxidant Normal human erythrocytes |
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