| 用药环境对药物敏化效应的调控作用 |
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| 引用本文： | 覃旺军,梁建辉.用药环境对药物敏化效应的调控作用[J].中国药理学通报,2011,27(12):1632-1635. |
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| 作者姓名： | 覃旺军 梁建辉 |
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| 作者单位： | 北京大学中国药物依赖性研究所,北京,100191 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目，国家自然科学基金资助项目，"十二五"科技支撑计划 |
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| 摘 要： | 用药环境在精神活性物质诱导的行为敏化效应中发挥重要作用。新异环境和匹配环境能明显调节药物诱导的行为敏化,使药物产生敏化的量效曲线左移。环境的调控作用表明成瘾记忆参与了行为敏化的形成过程。该文就用药环境对药物敏化的作用及机制作一综述。
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| 关 键 词： | 药物敏化 行为敏化 新异环境 匹配环境 条件作用 场景调节学说 成瘾记忆 |
The regulatory effect of drug associated environment on drug sensitization |
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| QIN Wang-jun,LIANG Jian-hui.The regulatory effect of drug associated environment on drug sensitization[J].Chinese Pharmacological Bulletin,2011,27(12):1632-1635. |
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| Authors: | QIN Wang-jun LIANG Jian-hui |
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| Institution: | QIN Wang-jun,LIANG Jian-hui(National Institute on Drug Dependence,Peking University,Beijing 100191,China) |
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| Abstract: | Drug associated environment is one of the most critical factors in behavioral sensitization induced by psychoactive substances.Novel environment and paired environment significantly regulate the drug induced behavioral sensitization and contribute to the left shift of the dose-effect curve for the induction of sensitization,which suggests the involvement of addiction memory.This paper systematically discusses the role of drug associated environment in drug sensitization and the underlying mechanisms. |
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| Keywords: | drug sensitization behavioral sensitization novel environment paired environment conditioning occasion-setting addiction memory |
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