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| HPLC测定结肠炎奇效颗粒中京尼平苷酸的含量 | |
| 引用本文： | 程东岩,李明洋,王友联,宋柏林,刘永宏.HPLC测定结肠炎奇效颗粒中京尼平苷酸的含量[J].中国药师,2011,14(9):1268-1269. |
| 作者姓名： | 程东岩 李明洋 王友联 宋柏林 刘永宏 |
| 作者单位： | 1. 吉林省中医药科学院 长春130012 2. 白求恩医科大学制药厂 3. 长春中医药大学附属医院 4. 中国科学院南海海洋研究所 |
| 基金项目： | 国家重大科技专项经费资助项目 |
| 摘 要： | 目的:建立结肠炎奇效颗粒中京尼平苷酸的HPLC测定方法。方法:色谱柱:Kromasil C18柱（250 mm×4.6 mm,5μm）,以甲醇-1%醋酸溶液（10:90）为流动相,检测波长为254 nm,柱温为30℃,流速为1 ml·min-1。结果:京尼平苷酸在0.306～3.666μg范围内线性关系良好,相关系数为r=0.9991,平均回收率为100.0%,RSD=1.91%（n=6）。结论:方法简便,结果准确,可用于结肠炎奇效颗粒的质量控制。 |
| 关 键 词： | 结肠炎奇效颗粒 京尼平苷酸 高效液相色谱法 |
Determination of Geniposidic Acid in Jiechangyan Qixiao Granules by HPLC |
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| Cheng Dongyan,Li Mingyang,Wang Youlian,Song Bailin,Liu Yonghong.Determination of Geniposidic Acid in Jiechangyan Qixiao Granules by HPLC[J].China Pharmacist,2011,14(9):1268-1269. | |
| Authors: | Cheng Dongyan Li Mingyang Wang Youlian Song Bailin Liu Yonghong |
| Institution: | Cheng Dongyan~1,Li Mingyang~2,Wang Youlian~2,Song Bailin~3,Liu Yonghong~4(1.Jilin Province Academy of Chinese Medicine,Changchun 130012,China,2.Pharmaceutical Factory of Bathune University of Medical Sciences,3.The Affiliated Hospital of Changchun University of Traditional Chinese Medicine,4.South China Sea Institute of Oceanology,Academia Sinica) |
| Abstract: | Objective： To establish an HPLC method for the determination of geniposidic acid in Jiechangyan Qixiao granules. Method： The Kromasil C18 column（250 mm ×4. 6 mm,5 μm） was used. The mobile phase was methanol-1% HAC （ 10： 90）. The flow rate was 1 ml. min^-1. The detection wavelength was 254 nm. The column temperature was set at 30 ℃. Result： The linear range of geniposidie acid was 0. 306-3. 666 μg（ r = 0. 999 1 ）. The average recovery was 100. 0% with RSD of 1.91% （ n = 6）. Conclusion ： The method is simple and accurate. It can be used for the quality control of Jiechangyan Qixiao granules. |
| Keywords: | Jiechangyan Qixiao granules Geniposidic acid HPLC |
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