| 脂肪乳剂用于亲脂类药物毒性救治的研究进展 |
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| 引用本文： | 彭玉璇,封小美,于布为. 脂肪乳剂用于亲脂类药物毒性救治的研究进展[J]. 中国药理学通报, 2011, 27(11): 1494-1496. DOI: 10.3969/j.issn.1001-1978.2011.11.005 |
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| 作者姓名： | 彭玉璇 封小美 于布为 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院麻醉科,上海,200025 |
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| 摘 要： | 长效局部麻醉药等亲脂类药物过量使用可导致心跳骤停,且肾上腺素等药物复苏成功率低。脂肪乳剂作为肠外营养在临床应用已有近50年的历史。近年发现脂肪乳剂还可用于治疗亲脂类局部麻醉药物所致的心脏毒性,但其确切机制尚不明确。今后应更深入地阐明其确切机制,并确立治疗标准。
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| 关 键 词： | 脂肪乳剂 亲脂类药物 局麻药毒性 脂类复苏 脂质池 救治机制 |
Research progress on lipid rescue of lipid emulsion in highly lipophilic medicine |
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| PENG Yu-xuan,FENG Xiao-mei,YU Bu-wei. Research progress on lipid rescue of lipid emulsion in highly lipophilic medicine[J]. Chinese Pharmacological Bulletin, 2011, 27(11): 1494-1496. DOI: 10.3969/j.issn.1001-1978.2011.11.005 |
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| Authors: | PENG Yu-xuan FENG Xiao-mei YU Bu-wei |
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| Affiliation: | PENG Yu-xuan,FENG Xiao-mei,YU Bu-wei(Dept of Anesthesiology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China) |
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| Abstract: | Over dose of highly lipophilic medicine such as long-acting local anesthetic should induce cardiac arrest,which is refractory to standard therapy.Lipid emulsion has been used in TNP for about 50 years,and recently it has been shown to reliably reverse intractable cardiac toxicity in either humans or animals,but the mechanism of lipid rescue remains unclear.Future areas of investigation will focus on the improvement of treatment regimes and better understanding of the mechanism of lipid rescue. |
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| Keywords: | lipid emulsion highly lipophilic medicine local anesthetic toxicity lipid rescue lipid sink mechanism of rescue |
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