| 眼用司帕沙星阳离子脂质体原位凝胶的研制 |
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| 引用本文： | 黄理,何文.眼用司帕沙星阳离子脂质体原位凝胶的研制[J].中国药师,2011,14(9):1285-1287. |
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| 作者姓名： | 黄理 何文 |
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| 作者单位： | 1. 武汉大学人民医院药学部 武汉430060;武汉大学药学院
2. 武汉大学人民医院药学部 武汉430060 |
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| 摘 要： | 目的:研制司帕沙星(SF)眼用阳离子脂质体-原位凝胶(ISG)。方法:采用pH梯度法制备SF脂质体(SFL),用季胺化程度为60%的N-三甲基壳聚糖(TMC60)包衣,用正交试验筛选其最佳处方及工艺,再与泊洛沙姆P407为基质的温度敏感材料混合,制备TMC60包衣的SFL-ISG,并对其形态、粒径、Zeta电位、凝胶溶蚀及释药等体外性质进行考察。结果:本品形态圆整,粒径分布均匀,TMC60包衣后Zeta电位由负转正,药物释放和凝胶溶蚀均呈现良好的零级释放特征。结论:本品结合阳离子脂质体与原位凝胶技术成功制备了TMC60包衣的SFL-ISG,为其体内研究奠定了实验基础。
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| 关 键 词： | 司帕沙星 阳离子脂质体 原位凝胶 |
Study on Preparation of Ocular Sparfloxacin Cationic Liposomal ln-situ Gels |
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| Huang Li,He Wen.Study on Preparation of Ocular Sparfloxacin Cationic Liposomal ln-situ Gels[J].China Pharmacist,2011,14(9):1285-1287. |
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| Authors: | Huang Li He Wen |
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| Institution: | Huang Li~(1,2),He Wen~1(1.Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China,2.School of Pharmaceutical Science,Wuhan University) |
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| Abstract: | Objective:To prepare ocular cationic liposomal in-situ gels(ISG) containing sparfloxacin(SF).Method:SF liposomes (SFL) were prepared by pH gradient method followed by N-trimethyl chitosan with quarternization of 60%(TMC60) coating. The optimal formulation and preparation process were screened by orthogonal experiment.Poloxamer 407 was used as the base of the ISG combined with TMC60-coated SFL.The morphology,size,Zeta-potential,gel corrosion and SF release were studied in vitro.Result: The TMC60-coated SFL-I... |
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| Keywords: | Sparfloxacin Cationic liposomes In-situ gels |
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