| 心肌缺血与交感神经传入的研究进展 |
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| 引用本文： | 刘俊,梁尚栋. 心肌缺血与交感神经传入的研究进展[J]. 中国药理学通报, 2011, 27(12): 1629-1632. DOI: 10.3969/j.issn.1001-1978.2011.12.001 |
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| 作者姓名： | 刘俊 梁尚栋 |
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| 作者单位： | 南昌大学基础医学院生理学教研室,江西,南昌,330006 |
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| 基金项目： | 国家自然科学基金资助项目，江西省科技支撑计划-社会发展支撑计划重点资助项目 |
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| 摘 要： | 心脏的自主神经包括交感神经与副交感神经。支配心脏的交感神经不仅有传出轴突,也有传递心脏感受的传入神经。心肌缺血可激活心交感传入神经并将信息传递到大脑心血管中枢,通过兴奋交感传出神经引起交感兴奋性反射,出现心率加快和血压升高等现象使心肌缺血、缺氧和心绞痛加重。因此,交感神经功能变化可加重心肌缺血损伤。
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| 关 键 词： | 心肌缺血 心绞痛 交感传入神经 交感兴奋反射 炎性介质 伤害性感受器 |
Research progress of myocardial ischemia and sympathetic afferent |
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| LIU Jun,LIANG Shang-dong. Research progress of myocardial ischemia and sympathetic afferent[J]. Chinese Pharmacological Bulletin, 2011, 27(12): 1629-1632. DOI: 10.3969/j.issn.1001-1978.2011.12.001 |
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| Authors: | LIU Jun LIANG Shang-dong |
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| Affiliation: | LIU Jun,LIANG Shang-dong (Dept of Physiology,Basic Medical College of Nanchang University,Nanchang 330006) |
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| Abstract: | The heart autonomic nervous system consists of both sympathetic and parasympathetic nerves.The heart sympathetic nerves contain not only efferent axons, but also the afferent nerve(transmitting messages to the heart).Myocardial ischemia activates cardiac sympathetic afferent nerve and transmits the information to the brain and cardiovascular centre, which results in sympathetic reflex excitability by excitatory sympathetic efferent. This causes an increase in heart rate and blood pressure, leading to the de... |
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| Keywords: | myocardial ischemia angina sympathetic afferent nerve sympathetic reflex excitability inflammatory mediators nociceptorsre the change in sympathetic function is anociceptors |
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