| 安宫牛黄片粉末直接压片法工艺研究 |
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| 引用本文： | 杨敏茹,林瑶,王荣,顾宜,郭飞燕,王晓娟.安宫牛黄片粉末直接压片法工艺研究[J].中国药师,2011,14(9):1281-1283. |
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| 作者姓名： | 杨敏茹 林瑶 王荣 顾宜 郭飞燕 王晓娟 |
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| 作者单位： | 1. 陕西省新药评审中心 西安710065
2. 第四军医大学口腔医院药剂科 |
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| 基金项目： | 陕西省中医管理局中医药科研课题 |
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| 摘 要： | 目的:优选安宫牛黄片粉末直接压片法最佳制备工艺。方法:采用全粉末直接压片法,以粉末流动性和有效成分溶出度为评价指标选择最优处方并验证。通过稳定性试验,对安宫牛黄片的性状、含量、溶出度进行考察。结果:所选处方粉末流动性好,有效成分溶出速率高,各项指标均符合规定,稳定性良好。结论:该工艺简便、易行,可为工业化生产提供依据。
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| 关 键 词： | 安宫牛黄片 粉末直接压片法 制备工艺 |
Study on Direct Powder Compression Process of Angong Niuhuang Tablets |
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| Yang Minru,Lin Yao,Wang Rong,Gu Yi,Guo Feiyan,Wang Xiaojuan.Study on Direct Powder Compression Process of Angong Niuhuang Tablets[J].China Pharmacist,2011,14(9):1281-1283. |
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| Authors: | Yang Minru Lin Yao Wang Rong Gu Yi Guo Feiyan Wang Xiaojuan |
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| Institution: | Yang Minru~1,Lin Yao~2,Wang Rong~2,Gu Yi~2,Guo Feiyan~2,Wang Xiaojuan~2(1.New Medicine Evaluation Center,Xi'an 710065,China,2.Stomatology Hospital of the Fourth Military Medical University) |
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| Abstract: | Objective:To optimize the preparation process of Angong Niuhuang tablets by direct powder compression.Method: Angong Niuhuang tablets were prepared by direct powder compression.The influencing factors in the formulation of the tablets were optimized with powder fluidity and drug dissolution as the indicators.Stability of the tablets was evaluated with appearance,content and dissolution as the testing indices.Result:The selected formulation had promising powder fluidity and dissolution rate with good stabili... |
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| Keywords: | Angong Niuhuang tablets Direct powder compression Preparation process |
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