人工合成E-选择素治疗大鼠局灶脑缺血再灌注损伤的探讨

目的：探讨新的药物治疗脑缺血再灌注损伤。方法：用人工合成 Ｅ－选择素 ２ｍｇ·ｋｇ－１或 １０ ｍｇ·ｋｇ－１溶解于生理盐水中，静脉注入自发性高血压大鼠永久左侧大脑中动脉／颈总动脉（ＭＣＡ／ＣＣＡ）闭塞或ＭＣＡ／ＣＣＡ闭塞２ｈ后ＣＣＡ再灌注模型中。２４ｈ后，脑梗死体积用计算机扫描计算。结果：在永久性ＭＣＡ／ＣＣＡ闭死组中脑梗死体积没有差别，在ＭＣＡ／ＣＣＡ闭死后ＣＣＡ再灌注组中脑梗死体积有意义地缩小（Ｐ＜０．０１）。结论：Ｅ－选择素能够有效地减少大鼠脑缺血再灌注损伤。

Exploration of Treating Local Reperfusion Injury After Rat Cerebral Ischemia with Artificial Synthetic E-selectin

Aim :To explore a new drug to treat the local reperfusion injury after rat cerebral ischemia. Methods: A artificial synthetic E-selectin at a dosage of 2 mg. kg-1 was dissolved in physiological saline and injected intravenously in the model of spontaneously hypertensive rat (SHR ) left middle cerebral artery (MCA) and common carotid artery(CCA)were permanently occluded or reperfused the CCA after 2 hours of MCA/CCA occlusion. The volumes of cerebral infarct were calculated with computer tomography. Results :Infarct volumes were no different in permanent MCA and CCA occlusion groups and signifi- cantly reduced infarct volumes following permanent MCA occlusion plus transient 2-hour CCA occlusion groups. Conclusion: A artificial synthetic E-selectin can effectively reduce the reperfusion injury after cerebral ischemia.