| 6-取代胺基嘌呤衍生物的制备及抗菌活性研究 |
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| 引用本文： | 陆鸿飞,陆明.6-取代胺基嘌呤衍生物的制备及抗菌活性研究[J].中国医药工业杂志,2009,40(12). |
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| 作者姓名： | 陆鸿飞 陆明 |
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| 作者单位： | 1. 江苏科技大学材料科学与技术学院,江苏镇江,212003
2. 南京理工大学化工学院,江苏南京,210094 |
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| 摘 要： | 鸟嘌呤经酰化、氯化并水解得2-氨基-6-氯嘌呤,与苄硫醇反应所得2-氨基-6-苯甲硫基嘌呤,再与取代胺反应制得6-取代胺摹嘌呤衍生物1a～1d.体外抗菌活性试验结果表明,1a～1d对稻草芽孢杆菌抗菌活性较好,1b、1c和1d对黑曲酶抗菌活性较好,1c和1d对热带假丝酵母抗菌活性较好.
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| 关 键 词： | 6-取代胺基嘌呤衍生物 合成 抑菌活性 |
Synthesis and Antibacterial Activity of 6-Substituted Amino Purine Derivatives |
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| Authors: | LU Hong-fei LU Ming |
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| Abstract: | Four new 6-substituted amino purine derivatives were synthesized from guanine by acylation,chlorination and hydrolysis to give 2-amino-6-chloropurine,which was subjected to condensation with toluenethiol and then reaction with substituted amines.The antibacterial activity of the new compounds were tested in vitro and the results showed that 1a～1d exhibited good antibacterial activity against Bacillus subtilis,1b～1d exhibited activity against Aspergillus niger,1c and 1d exhibited activity against Candida tropicalis,respectively. |
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| Keywords: | 6-substituted amino pufine derivatives synthesis antibacterial activity |
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