| 肾脏病患者尿液中SIgA的含量的观察 |
| |
| 引用本文： | 马济民,程威英,冯菡芳,左静南,黄锦文,侯积寿,肖祥熊,吴继琮,方由仁,顾振辉,刘蝶.肾脏病患者尿液中SIgA的含量的观察[J].现代免疫学,1984(5). |
| |
| 作者姓名： | 马济民 程威英 冯菡芳 左静南 黄锦文 侯积寿 肖祥熊 吴继琮 方由仁 顾振辉 刘蝶 |
| |
| 作者单位： | 上海第二医学院附属新华医院内科
(马济民，程威英，冯菡芳，左静南，黄锦文，侯积寿)，上海第二医学院附属新华医院同位素科
(肖祥熊，吴继琮，方由仁，顾振辉)，上海第二医学院附属新华医院检验科(刘蝶) |
| |
| 摘 要： | 用放射免疫(双抗体-PEG法)测定109例正常人和85例各种类型肾脏病患者尿液中SIgA含量。表明慢性肾炎普通型、慢性肾炎肾病型活动期和慢性肾炎所引起的慢性肾功能不全均较正常对照组明显增高。慢性肾炎肾病型好转期尿 SIgA与正常对照组无显著差异,但较活动期明显减少。高分子和混合蛋白尿患者尿 SIgA较中分子和低分子蛋白尿患者明显增加。肾病患者24小时尿蛋白排出量与尿 SIgA呈正相关,而与血清 IgA无相关性。文中讨论了非感染性肾脏疾病时尿 SIgA增高的可能原因。
|
URINARY SECRETORY IMMUNOGLOBULIN A IN PATIENTS WITH RENAL DISEASES |
| |
| Abstract: | Urinary secretory immunoglobulin A (SIgA) was detected with radioimmunoassay (dual antibodies-PEG) in 109 normal adults and 85 patients with various renal diseases. Urinary SIgA was found markedly increased in patients with chronic glomerulonephritis, nephrotie syndrome and chronic nephritis with chronic renal failure as compared with normal controls. The urinary SIgA in normal adults was 0.3889± 0.3043 logX±logS (2.449g/mg creatinine). The levels of urinary SIgA in the nephrotic patients were significantly higher during the active stage than in remission. The number of cases with polycystic kidney, renal tubular acidosis, hereditary and gouty nephropathies was too small to reveal any significant difference in the levels of urinary SIgA from the normal controls.There was a positive correlation (r = 0.533) between the levels of urinary SIgA and protein excretion. Urinary SIgA might be produced by conjugating the filtered 7S IgA molecules with the secreting piece in the tubular epithelial cells. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
|
