Pathophysiology of preeclampsia

Preeclampsia is a multisystem disorder affecting about 5-10% of all pregnancies. It is a major cause of maternal, fetal and neonatal mortality and morbidity. Despite intensive research the etiology of this disease still remains unknown. Until now the inadequate transformation of the smooth-muscle cells of spiral arteries in the placental bed caused by an insufficient endovascular invasion of the trophoblast has been considered to be the major reason for the development of preeclampsia. Maternal-fetal (paternal) immune maladaptation is implicated in the insufficient trophoblast invasion, which leads to an imbalance of angiogenic and antiangiogenic factors at the maternal-fetal interface. This review summarizes the actual knowledge of important pathophysiological basic principles of preeclampsia.