| 急性肺栓塞溶栓治疗中ET-1和NO的动态变化及葛根素的干预作用 |
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| 引用本文： | 姜琴华,李国平,许雯,陈彦凡,王良兴,陈少贤.急性肺栓塞溶栓治疗中ET-1和NO的动态变化及葛根素的干预作用[J].医学研究杂志,2011,40(5):53-56. |
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| 作者姓名： | 姜琴华 李国平 许雯 陈彦凡 王良兴 陈少贤 |
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| 作者单位： | 1. 浙江省立同德医院,杭州,310012
2. 温州医学院附属第一医院,325000 |
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| 基金项目： | 浙江省中医药科技计划资助项目 |
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| 摘 要： | 目的研究急性肺栓塞溶栓治疗中内皮素-1(ET-1)和一氧化氮(NO)的动态变化及葛根素的干预作用。方法日本大耳白兔21只,随机分为假手术组(A组)、溶栓组(B组)、溶栓+葛根素组(C组)。自体血栓经右心导管注入,制备兔急性肺栓塞模型。心导管法监测肺动脉压,各组在栓塞前、栓塞后2h、溶栓后2h、4h检测血浆中ET-1和NO含量;光镜、电镜观察肺组织病理。结果在溶栓开始后1h,B组和C组肺动脉平均压(mPAP)即显著下降(P<0.01),且C组mPAP明显低于B组(P<0.05);在栓塞后2h、溶栓后2h、4h,B组和C组血浆ET-1含量均明显高于栓塞前(P<0.05,P<0.01),而NO含量明显低于栓塞前(P<0.05,P<0.01);与B组同期比较,C组在溶栓后2h、4h血浆ET-1和NO含量分别有明显下降和升高(P<0.05,P<0.01)。组织病理显示,C组肺组织结构破坏减轻,血管内皮细胞和肺泡Ⅱ型上皮细胞损伤较B组明显减轻。结论葛根素可有效提高急性肺栓塞溶栓后血浆中NO含量和减低ET-1含量,有内皮保护作用,对溶栓治疗后再灌注损伤有保护作用。
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| 关 键 词： | 肺栓塞 溶栓治疗 内皮素-1 一氧化氮 葛根素 |
| 收稿时间： | 2010/9/19 0:00:00 |
| 修稿时间： | 2011/3/28 0:00:00 |
Effect of Puerarin on the Dynamic Change of Endothelin-1 and Nitric Oxide During Thrombolytic Therapy in Acute Pulmonary Thromboembolism |
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| Jiang Qinhua,Li Guoping,Xu Wen,Chen Yanfan,Wang Liangxing,Chen Shaoxian.Effect of Puerarin on the Dynamic Change of Endothelin-1 and Nitric Oxide During Thrombolytic Therapy in Acute Pulmonary Thromboembolism[J].Journal of Medical Research,2011,40(5):53-56. |
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| Authors: | Jiang Qinhua Li Guoping Xu Wen Chen Yanfan Wang Liangxing Chen Shaoxian |
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| Institution: | Jiang Qinhua,Li Guoping,Xu Wen,Chen Yanfan,Wang Liangxing,Chen Shaoxian.Tongde Hospital of Zhejiang Province,Zhejiang 310012,China |
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| Abstract: | Objective To study the dynamic change of endothelin-1(ET-1) and nitric oxide(NO)during thrombolytic therapy in acute pulmonary thromboembolism and to determine the effects of puerarin.Methods Twenty-one Japanese rabbits were randomly divided into sham operation group(A group),thrombolysis group(B group),and thrombolysis+puerarin group(C group).Acute pulmonary embolism models of rabbits were established by injection of autologous blood clots through the right heart catheters.Pulmonary arterial pressure was m... |
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| Keywords: | Pulmonary thromboembolism Thrombolytic therapy Endothelin-1 Nitric oxide Puerarin |
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